Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :28457809
Publication Date : //

Circulating inflammatory biomarkers in relation to brain structural measurements in a non-demented elderly population.

The aim of this investigation was to determine whether circulating inflammatory biomarkers c-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to structural brain measures assessed by magnetic resonance imaging (MRI). High-resolution structural MRI was collected on 680 non-demented elderly (mean age 80.1years) participants of a community-based, multiethnic cohort. Approximately three quarters of these participants also had peripheral inflammatory biomarkers (CRP, IL6, and ACT) measured using ELISA. Structural measures including brain volumes and cortical thickness (with both global and regional measures) were derived from MRI scans, and repeated MRI measures were obtained after 4.5years. Mean fractional anisotropy was used as the indicator of white matter integrity assessed with diffusion tensor imaging. We examined the association of inflammatory biomarkers with brain volume, cortical thickness, and white matter integrity using regression models adjusted for age, gender, ethnicity, education, APOE genotype, and intracranial volume. A doubling in CRP (b=-2.48, p=0.002) was associated with a smaller total gray matter volume, equivalent to approximately 1.5years of aging. A doubling in IL6 was associated with smaller total brain volume (b=-14.96, p<0.0001), equivalent to approximately 9years of aging. Higher IL6 was also associated with smaller gray matter (b=-6.52, p=0.002) and white matter volumes (b=-7.47, p=0.004). The volumes of most cortical regions including frontal, occipital, parietal, temporal, as well as subcortical regions including pallidum and thalamus were associated with IL6. In a model additionally adjusted for depression, vascular factors, BMI, and smoking status, the association between IL6 and brain volumes remained, and a doubling in ACT was marginally associated with 0.054 (p=0.001) millimeter thinner mean cortical thickness, equivalent to that of approximately 2.7years of aging. None of the biomarkers was associated with mean fractional anisotropy or longitudinal change of brain volumes and thickness. Among older adults, increased circulating inflammatory biomarkers were associated with smaller brain volume and cortical thickness but not the white matter tract integrity. Our preliminary findings suggest that peripheral inflammatory processes may be involved in the brain atrophy in the elderly.

Authors : Gu Yian , Vorburger Robert , Scarmeas Nikolaos , Luchsinger José A , Manly Jennifer J , Schupf Nicole , Mayeux Richard , Brickman Adam M ,

Related products :

Catalog number Product name Quantity
25-611 SFRS3 belongs to the splicing factor SR family. It contains 1 RRM (RNA recognition motif) domain. It may be involved in RNA processing in relation with cellular proliferation and_or maturation. 0.05 mg
KMCH220B Advanced Full- functional Elderly Nursing Manikin
KMCH220A Advanced Full- functional Elderly Nursing Manikin
KMCH230 Advanced Wearable Elderly Action Simulation Suit
KMC220A Advanced Full-Functional Elderly Nursing Manikin
KMC220B Advanced Full-Functional Elderly Nursing Manikin
KMCH240 Advanced Wearable Simulation Suit for Elderly Hemiparalysis Nursing
PAB105P Polyclonal antibody Biomarkers, Bromodeoxyuridine-5 (BrdU) 250ug
MAB215P Mouse Monoclonal antibody Biomarkers, Cortisol
MAB118P Mouse Monoclonal antibody Biomarkers, Human Ferritin
MAB208P Mouse Monoclonal antibody Biomarkers, Human Myeloperoxidase
MAB222P Mouse Monoclonal antibody Biomarkers, Human Osteopontin
MAB209P Mouse Monoclonal antibody Biomarkers, Human Myeloperoxidase
PAB105H Polyclonal antibody Biomarkers, Bromodeoxyuridine-5 (BrdU)- HRP conjugated 250ug
MAB101P Mouse Monoclonal antibody Biomarkers, Alpha-fetoprotein (AFP)
MAB195P Mouse Monoclonal antibody Biomarkers, Human Osteopontin, N-terminal
MAB197P Mouse Monoclonal antibody Biomarkers, Human Osteopontin, C-terminal
MAB196P Mouse Monoclonal antibody Biomarkers, Human Osteopontin, N-terminal
MAB194P Mouse Monoclonal antibody Biomarkers, Human Osteopontin, N-terminal
MAB193P Mouse Monoclonal antibody Biomarkers, Human Osteopontin, N-terminal
PAB105B Polyclonal antibody Biomarkers, Bromodeoxyuridine-5 (BrdU)- Biotin conjugated 250ug
MAB149P Mouse Monoclonal antibody Biomarkers, Angiotensin II, Type 1 receptor
MABPTA4P Mouse Monoclonal antibody Biomarkers, Human Pancreatic Tumor Antigen
MAB198P Mouse Monoclonal antibody Biomarkers, Collagen Triple Helix Repeat Containing 1 (Cthrc1)
26-812 LPP may play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation 0.05 mg

https://antibody-antibodies.com/ | https://gentaur.com/ | https://gen-script.com/ | https://diagenox.com/ | https://clonagen.com/ | http://gentaursearch.com/ | http://gentaurpub.com/ | https://gentaur-online.com/ | http://anti-anti-pdf.com/ | http://gentaur-worldwide.com/


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur

Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur