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Pubmed ID :28632940
Publication Date : //

Characterization of the I4399M variant of apolipoprotein(a): implications for altered prothrombotic properties of lipoprotein(a).


Essentials Elevated lipoproteinp(a) is an independent and causal risk factor for atherothrombotic diseases. rs3798220 (Ile/Met substitution in apo(a) protease-like domain) is associated with disease risk. Recombinant I4399M apo(a) altered clot structure to accelerate coagulation/delay fibrinolysis. Evidence was found for increased solvent exposure and oxidation of Met residue.

Authors : Scipione C A , McAiney J T , Simard D J , Bazzi Z A , Gemin M , Romagnuolo R , Macrae F L , Ariëns R A , Hegele R A , Auld J , Gauld J W , Boffa M B , Koschinsky M L ,

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