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Pubmed ID :28714866
Publication Date : //

Ibrutinib treatment improves T cell number and function in CLL patients.

Ibrutinib has been shown to have immunomodulatory effects by inhibiting Bruton's tyrosine kinase (BTK) and IL-2-inducible T cell kinase (ITK). The relative importance of inhibiting these 2 kinases has not been examined despite its relevance to immune-based therapies.

Authors : Long Meixiao , Beckwith Kyle , Do Priscilla , Mundy Bethany L , Gordon Amber , Lehman Amy M , Maddocks Kami J , Cheney Carolyn , Jones Jeffrey A , Flynn Joseph M , Andritsos Leslie A , Awan Farrukh , Fraietta Joseph A , June Carl H , Maus Marcela V , Woyach Jennifer A , Caligiuri Michael A , Johnson Amy J , Muthusamy Natarajan , Byrd John C ,

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