Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :28745655
Publication Date : //

[Significance of anti-myelin basic protein antibodies for ocular hydrodynamic disturbances in primary open-angle glaucoma].


The aim of the study was to investigate the significance of anti-myelin basic protein (MBP) antibodies (AB) for ocular hydrodynamic disturbances in primary open-angle glaucoma (POAG). The study was conducted using the enzyme-linked immunosorbent assay (ELISA). The patients included had either high-tension (82 cases), or normal-tension (62 patients) glaucoma (HTG and NTG). In 46.3% of HTG patients and 38.7% of NTG patients, anti-MBP antibodies were lower than in the controls. There were also some cases (12.9%) of increased AB production at NTG onset. According to the canons of immunology, a decrease in anti-MBP antibodies can be explained by their binding to the protein and an increase - by stimulation of AB production through antigen release. In other words, antigen release must precede an increase in antibodies, which, in turn, must be followed by a subsequent decrease. In this aspect, an increase in anti-MBP antibody production at the stage of early hydrodynamic disturbances (NTG) and its decrease at the stage of pronounced changes (HTG) are perfectly natural. The level of anti-MBP antibodies correlated with the following indicators of ocular hydrodynamics: aqueous humor secretion (r=0.20841, p<0.05), intraocular pressure (r=-0.24046, р<0.05), ease of outflow (r=-0, 21552; р<0.05), and Becker's coefficient that reflects dissociation of control mechanisms in the regulation of hydrodynamics (r=-0.21683, p<0.05). The authors came to the conclusion that catalytic antibodies to MBP (also able to cause destruction of the myelin sheath of axons) play an important role in the pathogenesis of open-angle glaucoma. A decrease as well as an increase in anti-MBP antibodies has an unfavorable effect on ocular hydrodynamics. A theory has been put forward that these disorders may be induced by demyelination of peripheral nervous system axons involved in the regulation of intraocular fluid secretion and outflow.

Authors : Frolov M A , Likhvantseva V G , Kovelenova I V , Solomatina M V ,

Related products :

Catalog number Product name Quantity
GLC1K GLC1I Gene glaucoma 1, open angle, I
GLC1F GLC1C Gene glaucoma 1, open angle, C
GLC2A GLC1M Gene glaucoma 1, open angle, M (juvenile-onset)
GLC1N GLC1L Gene glaucoma 1, open angle, L (adult-onset)
GLC1H GLC1D Gene glaucoma 1, open angle, D (adult-onset)
GLC3B GLC1N Gene glaucoma 1, open angle, N (juvenile-onset)
GLC1M GLC1K Gene glaucoma 1, open angle, K (juvenile-onset)
GLC1I GLC1F Gene glaucoma 1, open angle, F (adult-onset)
GLC1J GLC1H Gene glaucoma 1, open angle, H (adult-onset)
GLC1D GLC1B Gene glaucoma 1, open angle, B (adult-onset)
GLC1L GLC1J Gene glaucoma 1, open angle, J (juvenile-onset)
orb26632 Myelin Basic Protein antibody Monoclonal Antibodies Primary antibodies 0.5 mg
orb26773 Myelin Basic Protein antibody Monoclonal Antibodies Primary antibodies 2 ml
orb22943 Myelin Basic Protein antibody Polyclonal Antibodies Primary antibodies 100
20-272-190416 Myelin Basic Protein - Mouse monoclonal [22] to Myelin Basic Protein; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein Monoclonal 1 ml
20-272-190388 Myelin Basic Protein - Mouse monoclonal [26] to Myelin Basic Protein; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein Monoclonal 1 ml
LF-MA41472 anti-Myelin Basic Protein, Mouse monoclonal to Myelin Basic Portein, Isotype IgG2b, Host Mouse 50 ug
orb82267 Myelin Basic protein Myelin Basic Protein >90 percent Pure is a purified neuroscience reagent. For research use only. 1 mg
18-272-196401 Myelin Basic Protein prediluted - Rabbit polyclonal to Myelin Basic Protein prediluted; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein Polyclonal 7 ml
orb60508 Travoprost Travoprost is a topical medication used for controlling the progression of glaucoma or ocular hypertension. For research use only. 5 mg
18-272-197086 Myelin Basic Protein - Oligodendrocyte Marker - Rabbit polyclonal to Myelin Basic Protein - Oligodendrocyte Marker; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein Polyclonal 0.25 ml
U0539h CLIA Homo sapiens,Human,MBP,MBP,Myelin A1 protein,Myelin basic protein,Myelin membrane encephalitogenic protein 96T
E0539h ELISA kit Homo sapiens,Human,MBP,MBP,Myelin A1 protein,Myelin basic protein,Myelin membrane encephalitogenic protein 96T
E0539h ELISA Homo sapiens,Human,MBP,MBP,Myelin A1 protein,Myelin basic protein,Myelin membrane encephalitogenic protein 96T
orb60394 Bimatoprost Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. For research use only. 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur