Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :28771341
Publication Date : 2017/08/03

Soyasapogenol B and Genistein Attenuate Lipopolysaccharide-Induced Memory Impairment in Mice by the Modulation of NF-κB-Mediated BDNF Expression.


Lactobacillus plantarum C29-fermented defatted soybean (FDS), which contains soyasaponins such as soyasaponin I (SI) and soyasapogenol B (SB) and isoflavones such as genistin (GE) and genistein (GT), attenuated memory impairment in mice. Moreover, in the preliminary study, FDS and its soyasaponins and isoflavones significantly inhibited NF-κB activation in LPS-stimulated microglial BV2 cells. Therefore, we examined the effects of FDS and its constituents SI, SB, GT, and GE on LPS-induced memory impairment in mice. Oral administration of FDS (80 mg/kg), which has higher concentrations of SB and GE than DS, recovered LPS-impaired cognitive function in Y-maze (55.1 ± 3.5%) and passive avoidance tasks (50.9 ± 19.2 s) to 129.2% (74.1 ± 3.5%) and 114.2% (290.0 ± 22.4 s) of normal mice, respectively (P < 0.05). SB and GE (10 μM) also more potently attenuated LPS-impaired cognitive behavior than SI and GT, respectively. SB (10 mg/kg) was the most effective: treatment recovered LPS-impaired spontaneous alternation and latency time to 105.7% and 126.8% of normal control mice, respectively (P < 0.05). SB and GE significantly increased BDNF expression and CREB phosphorylation in LPS-treated mice and corticosterone-stimulated SH-SY5Y cells. Furthermore, SB and GE (10 μM) also significantly inhibited NF-κB activation in LPS-treated mice. These findings suggested that FDS and its constituent soyasaponins and isoflavones may attenuate memory impairment by the regulation of NF-κB-mediated BDNF expression.

Authors : Lee Hae-Ji , Lim Su-Min , Ko Da-Bin , Jeong Jin-Ju , Hwang Yun-Ha , Kim Dong-Hyun ,

Related products :

Catalog number Product name Quantity
EIAAB44625 CXorf15,ELRG,Environmental lipopolysaccharide-responding gene protein,Factor inhibiting ATF4-mediated transcription,FIAT,Gamma-taxilin,Homo sapiens,Human,Lipopolysaccharide-specific response protein 5
30-197 Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cel 0.1 mg
28-795 IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth 0.1 mg
30-158 Hearing impairment is a heterogeneous condition with over 40 loci described. DFNA5 is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with 0.1 mg
EIAAB44624 Factor inhibiting ATF4-mediated transcription,FIAT,Gamma-taxilin,Lipopolysaccharide-responsive gene protein,Lrg,Mouse,Mus musculus,Txlng
RPR-350 Recombinant Human Lipopolysaccharide-Induced TNF Factor 5
ASCITE-1 Custom Production of Ascites in Balb c mice (min 20 mice @$30 mice plus; $300 per cell line for cell culture) 1
pro-1350 Recombinant Human Lipopolysaccharide-Induced TNF Factor 1mg
ant-443 Mouse Anti Human Lipopolysaccharide-induced TNF factor 5
E13529h Human Lipopolysaccharide Induced TNF Factor ELISA 96T
201-20-3129 LITAF{lipopolysaccharide-induced TNF factor}rabbit.pAb 0.2ml
pro-1350 Recombinant Human Lipopolysaccharide-Induced TNF Factor 20
ant-443 Mouse Anti Human Lipopolysaccharide-induced TNF factor 20
LIX1L LITAF Gene lipopolysaccharide-induced TNF factor
pro-1350 Recombinant Human Lipopolysaccharide-Induced TNF Factor 5
RAN-443 Mouse Anti Human Lipopolysaccharide-induced TNF factor 5
ant-443 Mouse Anti Human Lipopolysaccharide-induced TNF factor 100
OETAbs443 Lipopolysaccharide-induced TNF factor, Mouse Anti Human 5
ant-443 Mouse Anti Human Lipopolysaccharide-induced TNF factor LITAF 100
ant-443 Mouse Anti Human Lipopolysaccharide-induced TNF factor LITAF 5
OETAbs443 Lipopolysaccharide-induced TNF factor, Mouse Anti Human 20
ant-443 Mouse Anti Human Lipopolysaccharide-induced TNF factor LITAF 20
orb61038 Genistein Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. For research use only. 1 g
orb60336 Genistein Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. For research use only. 50 mg
8-00120 Mouse Anti Human Lipopolysaccharide-induced TNF factor, antibody 5


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur