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Pubmed ID :28843696
Publication Date : //

NGF protects endothelial cells from indomethacin-induced injury through activation of mitochondria and upregulation of IGF-1.


Endothelial cells (ECs) lining blood vessels are critical for delivery of oxygen and nutrients to all tissues and organs and play a crucial role in the regeneration of blood vessel following tissue injury. ECs are also major targets of injury by a variety of noxious factors [e.g., ethanol and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin, diclofenac], especially in gastric mucosa that has direct exposure to these agents. In this study, we investigated whether nerve growth factor (NGF) can protect gastric microvascular ECs (GECs) from injury by indomethacin (INDO) and the mechanisms involved.

Authors : Ahluwalia Amrita , Jones Michael K , Hoa Neil , Tarnawski Andrzej S ,

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