Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :28849101
Publication Date : //

CD147 blockade as a potential and novel treatment of graft rejection.


Cluster of differentiation (CD)147 is highly involved in the T cell activation process. High CD147 expression is observed on the surfaces of activated T cells, particularly CD4+ T cells. In organ transplantation, it is important to prevent graft rejection resulting from the excessive activation of T cells, particularly CD4+ T cells, which exhibit a key role in amplifying the immune response. The present study aimed to investigate the effects of CD147 blockade in vitro and in vivo and used a transplant rejection system to assess the feasibility of utilizing CD147 antibody‑based immunosuppressant drugs for the treatment of graft rejection. The effects of CD147 antibodies were evaluated on lymphocyte proliferation stimulated by phytohemagglutinin or CD3/CD28 magnetic beads and in a one‑way mixed lymphocyte reaction (MLR) system in vitro. For the in vivo analysis, an allogeneic skin transplantation mouse model was used. CD147 antibodies were effective against lymphocytes, particularly CD4+T lymphocytes, and were additionally effective in the one‑way MLR system. In the allogeneic skin transplantation mouse model, the survival of transplanted skin was extended in the CD147 antibody‑treated group. Furthermore, the level of inflammatory cell infiltration in transplanted skin was reduced. CD147 blockade decreased the serum levels of interleukin (IL)‑17 and the proportions of peripheral blood CD4+ and CD8+ memory T cells. The data demonstrated that CD147 blockade suppressed skin graft rejection, primarily by suppressing CD4+T and memory T cell proliferation, indicating that CD147 exhibits great potential as a target of immunosuppressant drugs.

Authors : Luan Jing , Zhao Yu , Zhang Yang , Miao Jinlin , Li Jia , Chen Zhi-Nan , Zhu Ping ,

Related products :

Catalog number Product name Quantity
26-462 ITFG1 belongs to the TIP family. It contains 1 FG-GAP repeat. ITFG1 is a modulator of T-cell function. It has a protective effect in graft versus host disease model. 0.05 mg
EIAAB44103 Long transient receptor potential channel 7,LTrpC7,LTrpC-7,Rat,Rattus norvegicus,Transient receptor potential cation channel subfamily M member 7,Transient receptor potential-phospholipase C-interacti
103-M380 CD147 Anti-Mouse Host: Rat Bsg; HT-7; CD147; EMMPRIN; AI115436; AI325119 100
103-M380 CD147, Host: Rat, Species: Anti-Mouse, Synonyms: Bsg; HT-7; CD147; EMMPRIN; AI115436; AI325119 100 ug
A4-274-T025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 25 tests
A4-274-T100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 100 tests
A6-274-T025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 25 tests
A6-274-T100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 100 tests
A7-274-T025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 25 tests
A7-274-T100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 100 tests
10-507-C025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 0.025 mg
11-454-C100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG2b Antigen CD147 Isotype IgG2b 0.1 mg
1P-274-T100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 100 tests
1P-274-T025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 25 tests
1F-274-T100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 100 tests
11-274-C100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 0.1 mg
10-507-C100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 0.1 mg
11-274-C025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 0.025 mg
11-454-C025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG2b Antigen CD147 Isotype IgG2b 0.025 mg
1A-274-T025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 25 tests
1A-274-T100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 100 tests
1B-274-C025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 0.025 mg
1B-274-C100 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 0.1 mg
1F-274-T025 Mouse Monoclonal to CD147 _ Basigin _ Neurothelin Antigen CD147 Isotype IgG1 Antigen CD147 Isotype IgG1 25 tests
EIAAB44106 Homo sapiens,Human,Long transient receptor potential channel 6,LTrpC6,LTRPC6,LTrpC-6,Transient receptor potential cation channel subfamily M member 8,Transient receptor potential p8,TRPM8,TRPP8,Trp-p8


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur