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ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
High-density lipoproteins (HDL) are considered to protect against atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues. However, factors regulating lipid efflux are incompletely understood. We previously identified a variant in adenosine triphosphate-binding cassette transporter A8 () in an individual with low HDL cholesterol (HDLc). Here, we investigate the role of ABCA8 in cholesterol efflux and in regulating HDLc levels.
Authors : Trigueros-Motos Laia , van Capelleveen Julian C , Torta Federico , Castaño David , Zhang Lin-Hua , Chai Ee Chu , Kang Martin , Dimova Lidiya G , Schimmel Alinda W M , Tietjen Ian , Radomski Chris , Tan Liang Juin , Thiam Chung Hwee , Narayanaswamy Pradeep , Wu Daniel Heqing , Dorninger Fabian , Yakala Gopala Krishna , Barhdadi Amina , Angeli Veronique , Dubé Marie-Pierre , Berger Johannes , Dallinga-Thie Geesje M , Tietge Uwe J F , Wenk Markus R , Hayden Michael R , Hovingh G Kees , Singaraja Roshni R ,
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Pathways :
WP103: Cholesterol Biosynthesis
WP1070: Cholesterol Biosynthesis
WP1186: Cholesterol Biosynthesis
WP132: Cholesterol Biosynthesis
WP1387: Cholesterol Biosynthesis
WP1633: Bisphenol A degradation
WP1634: Butanoate metabolism
WP1652: Fructose and mannose metabolism
WP1666: Linoleic acid metabolism
WP1795: Cholesterol biosynthesis
WP197: Cholesterol Biosynthesis
WP2011: SREBF and miR33 in cholesterol and lipid homeostasis
WP2084: SREBF and miR33 in cholesterol and lipid homeostasis
WP461: Cholesterol Biosynthesis
WP632: Cholesterol metabolism
WP659: Cholesterol metabolism
WP833: Cholesterol Biosynthesis
WP952: Cholesterol Biosynthesis
WP1810: Elevation of cytosolic Ca2+ levels
Related Genes :
Bibliography :
[28882873] ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
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