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Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children.
α-Klotho is a transmembrane protein that can be cleaved and act as a circulating hormone (s-klotho). s-Klotho serum levels seem to reflect growth hormone (GH) secretory status. We investigated the role of s-klotho as a reliable marker of GH secretion in short children and the factors influencing its secretion.
Authors : Meazza Cristina , Elsedfy Heba H , Khalaf Randa I , Lupi Fiorenzo , Pagani Sara , Kholy Mohamed El , Tinelli Carmine , Radetti Giorgio , Bozzola Mauro ,
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Pathways :
WP1065: Endochondral Ossification
WP1181: Endochondral Ossification
WP1270: Endochondral Ossification
WP1308: Endochondral Ossification
WP1383: Endochondral Ossification
WP474: Endochondral Ossification
WP828: Endochondral Ossification
WP947: Endochondral Ossification
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1531: Vitamin D synthesis
WP1614: 1- and 2-Methylnaphthalene degradation
WP1624: Bacterial secretion system
WP1626: Benzoate degradation via CoA ligation
WP1633: Bisphenol A degradation
WP1647: Fatty acid biosynthesis
WP1654: gamma-Hexachlorocyclohexane degradation
WP1665: Limonene and pinene degradation
WP1673: Naphthalene and anthracene degradation
WP1708: Terpenoid backbone biosynthesis
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1810: Elevation of cytosolic Ca2+ levels
WP1866: NCAM signaling for neurite out-growth
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Bibliography :
[30718148] Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Mexican Diabetic Patients and Its Association With Early Nephropathy.
[30551370] Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes.
[30535376] Low magnesium diet aggravates phosphate-induced kidney injury.
[30429202] Fractional excretion of phosphorus and vascular calcification in stage 3 chronic kidney disease.
[30393837] Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi).
[30250491] Aging and sex affect soluble alpha klotho levels in bonobos and chimpanzees.
[30170389] Impact of cigarette smoking cessation on plasma α-klotho levels.
[30147756] High-intensity physical exercise increases serum -klotho levels in healthy volunteers.
[30115946] Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study.
[30064142] Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis.
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