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Pubmed ID :29023759
Publication Date : //

Cord blood-derived T cells allow the generation of a more naïve tumor-reactive cytotoxic T-cell phenotype.


Transplantation of hematopoietic stem cells (HSCs) from peripheral blood (PB) or cord blood (CB) is well established. HSCs from CB are associated with a lower risk of graft-versus-host disease (GVHD), but antigen-independent expanded CB- and PB-derived T cells can induce GVHD in allo-HSC recipients. CB-derived cells might be more suitable for adoptive immunotherapy as they have unique T-cell characteristics. Here, we describe functional differences between CB and PB T cells stimulated with different cytokine combinations involved in central T-cell activation.

Authors : Kwoczek Julian , Riese Sebastian B , Tischer Sabine , Bak Szilvia , Lahrberg Julia , Oelke Mathias , Maul Holger , Blasczyk Rainer , Sauer Martin , Eiz-Vesper Britta ,

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