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Effects of growth hormone therapy on bone density and fracture risk in age-related osteoporosis in the absence of growth hormone deficiency: a systematic review and meta-analysis.
In adults, growth hormone deficiency (GHD) has been associated with low bone mineral density (BMD), an effect counteracted by growth hormone (GH) replacement. Whether GH is beneficial in adults with age-related bone loss and without hypopituitarism is unclear.
Authors : Barake Maya , Arabi Asma , Nakhoul Nancy , El-Hajj Fuleihan Ghada , El Ghandour Sarah , Klibanski Anne , Tritos Nicholas A ,
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Pathways :
WP1065: Endochondral Ossification
WP1181: Endochondral Ossification
WP1270: Endochondral Ossification
WP1308: Endochondral Ossification
WP1383: Endochondral Ossification
WP474: Endochondral Ossification
WP828: Endochondral Ossification
WP947: Endochondral Ossification
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1531: Vitamin D synthesis
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1866: NCAM signaling for neurite out-growth
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1981: Thyroxine (thyroid hormone) production
WP2256: Integrated Pancreatic Cancer Pathway
WP2355: Corticotropin-releasing hormone
WP2377: Integrated Pancreatic Cancer Pathway
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
Related Genes :
[malK b4035 JW3995] Maltose/maltodextrin import ATP-binding protein MalK (EC 3.6.3.19)
[ZC3H12A MCPIP MCPIP1] Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)
[Prkcg Pkcc Pkcg Prkcc] Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)
[Mtrr] Methionine synthase reductase (MSR) (EC 1.16.1.8)
[Il27 Il27a] Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL-27-A) (IL27-A) (p28)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[PRKCG] Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) (PKC-delta)
[] Phospholipase A2 crotoxin basic subunit CBb (CTX subunit CBb) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
[Prkcg Pkcc Pkcg Prkcc] Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)
[hns bglY cur drdX hnsA msyA osmZ pilG topS b1237 JW1225] DNA-binding protein H-NS (Heat-stable nucleoid-structuring protein) (Histone-like protein HLP-II) (Protein B1) (Protein H1)
[Ffar4 Gpr120 O3far1] Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor GT01) (Omega-3 fatty acid receptor 1)
[] Phospholipase A2 crotoxin basic subunit CBc (CB1) (CTX subunit CBc) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
[csrA zfiA b2696 JW2666] Carbon storage regulator (Translational dual regulator CsrA)
[Arc] Activity-regulated cytoskeleton-associated protein (mArc) (Activity-regulated gene 3.1 protein) (ARC/ARG3.1) (Arg3.1)
[] DELTA-actitoxin-Aeq1a (DELTA-AITX-Aeq1a) (Equinatoxin II) (EqT II) (EqTII) (Equinatoxin-2)
[Cnr1] Cannabinoid receptor 1 (CB-R) (CB1) (Brain-type cannabinoid receptor)
[MAPT MAPTL MTBT1 TAU] Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
[] Phospholipase A2 crotoxin basic chain CBa2 (CB2) (CTX subunit CBa2) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Prkce Pkce Pkcea] Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)
[MKNK2 GPRK7 MNK2] MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
[cocE] Cocaine esterase (EC 3.1.1.84)
[PRKCG] Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) (Fragment)
[PRKCG QccE-17190] Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)
[PAK1] Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
[Pak1] Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (Protein kinase MUK2) (p21-activated kinase 1) (PAK-1) (p68-PAK)
[] L-amino-acid oxidase (Bf-LAAO) (LAAO) (LAO) (EC 1.4.3.2)
[] L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2)
[CRO2 CRT-P1] Crotamine (Crt) (Myotoxin)
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