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Pubmed ID :29040168
Publication Date : //

Failure of Isoflurane Cardiac Preconditioning in Obese Type 2 Diabetic Mice Involves Aberrant Regulation of MicroRNA-21, Endothelial Nitric-oxide Synthase, and Mitochondrial Complex I.


Diabetes impairs the cardioprotective effect of volatile anesthetics, yet the mechanisms are still murky. We examined the regulatory effect of isoflurane on microRNA-21, endothelial nitric-oxide synthase, and mitochondrial respiratory complex I in type 2 diabetic mice.

Authors : Ge Zhi-Dong , Li Yingchuan , Qiao Shigang , Bai Xiaowen , Warltier David C , Kersten Judy R , Bosnjak Zeljko J , Liang Mingyu ,

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