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Pubmed ID :29046921
Publication Date : 2017/10/19

Pioglitazone reduces cold-induced brown fat glucose uptake despite induction of browning in cultured human adipocytes: a randomised, controlled trial in humans.


Increasing brown adipose tissue (BAT) activity is a possible therapeutic strategy to increase energy expenditure and glucose and lipid clearance to ameliorate obesity and associated comorbidities. The thiazolidinedione (TZD) class of glucose-lowering drugs increase BAT browning in preclinical experimental models but whether these actions extend to humans in vivo is unknown. The aim of this study was to determine the effect of pioglitazone treatment on adipocyte browning and adaptive thermogenesis in humans.

Authors : Loh Rebecca K C , Formosa Melissa F , Eikelis Nina , Bertovic David A , Anderson Mitchell J , Barwood Shane A , Nanayakkara Shane , Cohen Neale D , La Gerche Andre , Reutens Anne T , Yap Kenneth S , Barber Thomas W , Lambert Gavin W , Cherk Martin H , Duffy Stephen J , Kingwell Bronwyn A , Carey Andrew L ,

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