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Pubmed ID :29055943
Publication Date : //

Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma.


A growing number of studies have demonstrated that the activity and expression level of sirtuin-1 (SIRT1) are decreased in asthma patients; however, the mechanisms underlying decreased SIRT1 expression and function are still not completely understood. Interleukin (IL)-6 plays important roles in inflammation during allergic asthma. In this study, we examined whether loss of SIRT1 activity regulated the expression of IL-6 and further verified the underlying mechanisms.

Authors : Tang Lingling , Chen Qingge , Meng Ziyu , Sun Li , Zhu Linyun , Liu Jinjin , Hu Junsheng , Ni Zhenhua , Wang Xiongbiao ,

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