Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29077981
Publication Date : //

Tissue-specific Differences in Immune Cell Subsets Located in the Naso-oropharyngeal-associated Lymphoid Tissues.


Defining the immune cells within the naso-oropharyngeal-associated lymphoid tissues would promote the development of efficient orally and nasally delivered immunotherapies. The aim was to compare murine antigen-presenting cells (APCs) and T cell subsets in the nose-associated lymphoid tissues (NALT), cervical lymph nodes (CLN), mesenteric lymph nodes (MLN) and peripheral lymph nodes (PLN) using flow cytometry and in vitro proliferation assays. Overall, the NALT contained a higher proportion of APCs and a lower proportion of T cells compared to the CLN, MLN and PLN. The APCs of the NALT more often belonged to the CD11c+ CD11b+ and the CD11cneg CD11b+ subsets as compared to the other sites. Both of these APC populations showed little sign of activation, that is low expression of the markers CD40, CD86 and IAd. Instead, the APCs of the NALT more often co-expressed CX3CR1 and CD206, markers associated with a tolerogenic function. No increase in the proportion of regulatory T cells was observed in the NALT. Instead, the T cells frequently exhibited a memory/effector phenotype, expressing the homing markers α4β7, CCR4 and CCR9, but rarely the naïve phenotype cell surface marker CD45RB. In contrast, the T cells at the other sites were mostly of the naïve phenotype. In addition, cells from the NALT did not proliferate upon in vitro stimulation with Con A, whereas the cells from the other sites did. Taken together, these results suggest that the NALT is primarily an effector site rather than one for activation and differentiation, despite it being regarded as a site of induction.

Authors : Bankvall M , Jontell M , Wold A , Östman S ,

Related products :

Catalog number Product name Quantity
'CC00-01-009 Human Squamous cell carcinoma, multiple organs tissues (22 different tissues) tissue array tissues 7 x 9
'GTX15410 Lymphoid (human) Abnormal appendicitis tissue slides tissues 5 slide
'GTX15409 Lymphoid (human) Abnormal granulomatous inflammation tissue slides tissues 5 slide
'GTX15407 Lymphoid (human) Abnormal granulomatous inflammation tissue slides tissues 5 slide
'GTX15408 Lymphoid (human) Abnormal granulomatous inflammation tissue slides tissues 5 slide
'CC00-01-009 Human Squamous cell carcinoma, multiple organs_tissues (22 different tissues) tissue array tissues 7 x 9
'CC02-02-002 Human Esophagus squamous cell carcinoma tissue array (self-matched with adjacent and normal tissues) tissues 6 x 9
'CC02-02-003 Human Esophagus squamous cell carcinoma tissue array (self-matched with adjacent and normal tissues) tissues 6 x 9
'CC02-02-001 Human Esophagus squamous cell carcinoma tissue array (self-matched with adjacent and normal tissues) tissues 6 x 9
'CC11-01-002 Human Ovary carcinoma tissue array (Adenocarcinoma, serous, endometrial, clear cell, small cell, granular cell, etc., with norma tissues 8 x 9
EIAAB33808 Mouse,Mus musculus,New ras effector 1,Nore1,RAPL,Rapl,Ras association domain-containing protein 5,Rassf5,Regulator for cell adhesion and polarization enriched in lymphoid tissues
29-678 There are at least four distinct but related alkaline phosphatases intestinal, placental, placental-like, and liver_bone_kidney (tissue non-specific). The first three are located together on chromoso 0.1 mg
EIAAB33807 Homo sapiens,Human,New ras effector 1,NORE1,RAPL,RAPL,Ras association domain-containing protein 5,RASSF5,Regulator for cell adhesion and polarization enriched in lymphoid tissues
'CC23-01-001 Human Testis carcinoma tissue array (Seminoma_spermatocytic_B-cell lymphoma, with normal tissue controls) tissues 7 x 9
'CC07-01-004 Human Kidney carcinoma tissue array (Clear cell granular cell transitional cell, with normal kidney) tissues 8 x 9
'CC07-01-002 Human Kidney carcinoma tissue array (Clear cell granular cell transitional cell nephroblastoma, with normal kidney) tissues 8 x 9
'CC02-01-002 Human Esophagus squamous cell carcinoma tissue array (Grade I ~ III, with normal esphoagus tissue controls) tissues 8 x 9
'CC23-01-001 Human Testis carcinoma tissue array (Seminoma spermatocytic B-cell lymphoma, with normal tissue controls) tissues 7 x 9
EIAAB45912 ATP6N1C,ATP6V0A3,Homo sapiens,Human,OC116,OC-116 kDa,Osteoclastic proton pump 116 kDa subunit,T-cell immune regulator 1,T-cell immune response cDNA7 protein,TCIRG1,TIRC7,Vacuolar proton translocating
'CS20-00-002 Human Lymphoma tissue array (Diffuse large cell B-cell T-cell Hodgkin lymphoma follicular diffuse B-cell, etc.) tissues 7 x 9
DR-010 Dog Tissue Total RNA, Adult Tissues Dog Tissue Total RNA Panel, any 10 Tissues except tissues marked with *, 25mg each 10x25mg
PR-010 Pig Tissue Total RNA, Adult Tissues Pig Tissue Total RNA Panel, any 10 Tissues except tissues marked with*, 25mg each 10x 25mg
'CC07-01-003 Human Kidney carcinoma tissue array, triplicate (clear cell granular cell chromophobe cell carcinoma, with normal kidney) tissues 7 x 9
28-193 The T-cell-specific transcription factor TCF7 activates genes involved in immune regulation and is a candidate locus for genetic susceptibility to type 1 diabetes. 0.05 mg
28-192 The T-cell-specific transcription factor TCF7 activates genes involved in immune regulation and is a candidate locus for genetic susceptibility to type 1 diabetes. 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur