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Pubmed ID :29096654
Publication Date : //

The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells.


Bone cancer pain (BCP) severely compromises the quality of life, while current treatments are still unsatisfactory. Here, we tested the antinociceptive effects of triptolide (T10), a substance with considerable anti-tumor efficacies on BCP, and investigated the underlying mechanisms targeting the spinal dorsal horn (SDH).

Authors : Hu Xiao-Fan , He Xiao-Tao , Zhou Kai-Xiang , Zhang Chen , Zhao Wen-Jun , Zhang Ting , Li Jin-Lian , Deng Jian-Ping , Dong Yu-Lin ,

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