Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29103463
Publication Date : //

Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs.

Ginkgo diterpene lactones meglumine injection (GDLI) is a commercially available product used for neuroprotection. However, the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI, i.e., ginkgolide A (GA), ginkgolide B (GB), and ginkgolide K (GK), have never been fully evaluated in beagle dogs. In this work, a simple, sensitive, and reliable method based on ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) was developed, and the prototypes and total amounts of GA, GB, and GK were determined in beagle dog plasma. The plasma concentrations of the hydrolyzed carboxylic forms were calculated by subtracting the prototype concentrations from the total lactone concentrations. For the first time, the pharmacokinetics of GA, GB, and GK were fully assessed in three forms, i.e., the prototypes, the hydrolyzed carboxylic forms, and the total amounts, after intravenous administration of GDLI in beagle dogs. It was shown that ginkgolides primarily existed in the hydrolyzed form in plasma, and the ratio of hydrolysates to prototype forms of GA and GB decreased gradually to a homeostatic ratio. All of the three forms of the three ginkgolides showed linear exposure of AUC to the dosages. GA, GB, and GK showed a constant half-life approximately 2.7, 3.4, and 1.2 h, respectively, which were consistent for the forms at three dose levels (0.3, 1.0, and 3.0 mg·kg) and after a consecutive injection of GDLI for 7 days (1.0 mg·kg).

Authors : Wang Shu-Yao , A Ji-Ye , Fei Fei , Geng Jian-Liang , Peng Ying , Ouyang Bing-Chen , Wang Pei , Jin Xiao-Liang , Zhao Yu-Qing , Wang Jian-Kun , Geng Ting , Li Yan-Jing , Huang Wen-Zhe , Wang Zhen-Zhong , Xiao Wei , Wang Guang-Ji ,

Related products :

Catalog number Product name Quantity
26099-09-2 Hydrolyzed Polymaleic Anhydride Hydrolyzed Polymaleic 1g
26099-09-2 Hydrolyzed Polymaleic Anhydride (HPM Hydrolyzed Polymaleic 1g
42461-84-7 Flunixin meglumine Flunixin meglumine 1g
42451-84-7 Flunmin Meglumine Flunmin Meglumine 1g
10532-59-9 Nitroxy(I)nil.Meglumine Nitroxy(I)nil.Meglumine 1g
69430-36-0 Keratin hydrolyzed Keratin hydrolyzed 1g
91080-18-1 Elastin, hydrolyzed Elastin, hydrolyzed 1g
96690-41-4 Silk hydrolyzed Silk hydrolyzed 1g
27-965 Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. Carboxypeptidase A1 is a monomeric 0.05 mg
KMMS48 Female Nursing Manikin—Betty Venipuncture and Injection Arm Simulator Rotated Arterial Puncture Arm Simulator Intramuscular Injection Simulator--Wear
131-49-7 Meglumine diatrizoate Meglumine diatrizoate 1g
orb60860 Bilobalide Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. For research use only. 10 mg
F455400 Flunixin Meglumine C21H28F3N3O7 CAS: 42461-84-7 10 mg
S08587 Starch (Hydrolyzed) 500 G
68412-29-3 Starch hydrolyzed 1g
S08587 Starch (Hydrolyzed) 1000 G
68412-29-3 Starch hydrolyzed, for gel elect 1g
orb61334 Forskolin Forskolin is a naturally occurring diterpene from the Indian plant, Coleus forskohlii, that works as an activator of adenylate cyclase resulting in an increase in the intracellular concentra 300 mg
orb60924 Tanshinone IIA Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardio 10 mg
948-60-7 Pterin-6-carboxylic acid Pterine-6-carboxylic aci 1g
SP-55238-1 C_Peptide, Dogs 0.5 mg
K 704 Identification of canine_specific DNA (dogs) 100 reactions
orb61231 Capecitabine Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. For research use only. 1 g
D445745 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (RS-Ofloxacin Carboxylic Acid) C13H9F2NO4 CAS: 82419-35-0 1 g
29-982 TYRP1 catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. It may regulate or influence the type of melanin synthesized. 0.1 mg


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur