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Pubmed ID :29109529
Publication Date : //

Glomerulocapillary miRNA response to HLA-class I antibody in vitro and in vivo.


Changes in miRNA expression glomerular of capillaries during antibody-mediated rejection (ABMR) are poorly understood and could contribute to the deleterious inflammation and fibrosis of ABMR via suppression of target genes. A better understanding could lead to novel diagnostic tools and reveal novel therapeutic targets. We explored deregulated miRNAs in an glomeruloendothelial in vitro model of ABMR due to class I human leukocyte antigen (HLA) with and without complement activation. We studied a set of 16 promising candidate miRNAs in microdissected glomeruli a confirmation set of 20 human transplant biopsies (DSA+) compared to 10 matched controls without evidence for ABMR. Twelve out of these 16 glomerulocapillary miRNAs could successfully be confirmed as dysregulated in vivo with 10 upregulated (let-7c-5p, miR-28-3p, miR-30d-5p, miR-99b-5p, miR-125a-5p, miR-195-5p, miR-374b-3p, miR-484, miR-501-3p, miR-520e) and 2 downregulated (miR29b-3p, miR-885-5p) in DSA+ vs.

Authors : Heinemann Falko M , Jindra Peter T , Bockmeyer Clemens L , Zeuschner Philip , Wittig Juliane , Höflich Heike , Eßer Marc , Abbas Mahmoud , Dieplinger Georg , Stolle Katharina , Vester Udo , Hoyer Peter F , Immenschuh Stephan , Heinold Andreas , Horn Peter A , Li Wentian , Eisenberger Ute , Becker Jan U ,

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