Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29123174
Publication Date : //

D-Cateslytin, a new antimicrobial peptide with therapeutic potential.


The rise of antimicrobial resistant microorganisms constitutes an increasingly serious threat to global public health. As a consequence, the efficacy of conventional antimicrobials is rapidly declining, threatening the ability of healthcare professionals to cure common infections. Over the last two decades host defense peptides have been identified as an attractive source of new antimicrobials. In the present study, we characterized the antibacterial and mechanistic properties of D-Cateslytin (D-Ctl), a new epipeptide derived from L-Cateslytin, where all L-amino acids were replaced by D-amino acids. We demonstrated that D-Ctl emerges as a potent, safe and robust peptide antimicrobial with undetectable susceptibility to resistance. Using Escherichia coli as a model, we reveal that D-Ctl targets the bacterial cell wall leading to the permeabilization of the membrane and the death of the bacteria. Overall, D-Ctl offers many assets that make it an attractive candidate for the biopharmaceutical development of new antimicrobials either as a single therapy or as a combination therapy as D-Ctl also has the remarkable property to potentiate several antimicrobials of reference such as cefotaxime, amoxicillin and methicillin.

Authors : Zaet Abdurraouf , Dartevelle Pauline , Daouad Fadoua , Ehlinger Claire , Quilès Fabienne , Francius Grégory , Boehler Christian , Bergthold Camille , Frisch Benoît , Prévost Gilles , Lavalle Philippe , Schneider Francis , Haïkel Youssef , Metz-Boutigue Marie-Hélène , Marban Céline ,

Related products :

Catalog number Product name Quantity
EIAAB05233 18 kDa cationic antimicrobial protein,CAMP,CAP18,CAP-18,Cathelicidin antimicrobial peptide,FALL39,hCAP-18,Homo sapiens,HSD26,Human
MCA5398Z MOUSE ANTI HUMAN HEPCIDIN ANTIMICROBIAL PEPTIDE Azide free, Product Type Monoclonal Antibody, Specificity HEPCIDIN ANTIMICROBIAL PEPTIDE, Target Species Human, Host Mouse, Format Azide Free, Isot 0.1 mg
orb71735 Human LL37 Antimicrobial peptide This is Human LL37 Antimicrobial peptide. For research use only. 1 mg
orb71970 SMAP 29, Sheep Myeloid Antimicrobial 29 peptide This is SMAP 29, Sheep Myeloid Antimicrobial 29 peptide. For research use only. 1 mg
TM 1501 ANTIMICROBIAL INHIBITOR AGAR pH 6.0 (for residual analysis of antimicrobial components in meat using Bacillus subtills and Micrococcus Iuteus (ATCC 9341) as test organisms.) 500 gm
TM 1503 ANTIMICROBIAL INHIBITOR AGAR pH 8.0 (for residual analysis of antimicrobial components in meat using Bacillus subtills and Micrococcus Iuteus (ATCC 9341) as test organisms.) 500 gm
LEAP21-P Anti_Human Liver_expressed antimicrobial peptide 2 (LEAP2) Control_blocking peptide 100 ug
LEAP22-P Anti_Human Liver_expressed antimicrobial peptide 2 (LEAP2) Control_blocking peptide 100 ug
LEAP21-P Anti-Human Liver-expressed antimicrobial peptide 2 (LEAP2) Control blocking peptide 100 ug
SP2321a LL - 37, Antimicrobial Peptide, human
SP2321a LL _ 37, Antimicrobial Peptide, human 1mg
SP2321b LL _ 37, Antimicrobial Peptide, human 5mg
KP1093 LL - 37, Antimicrobial Peptide, human 1 mg
SP2321a LL - 37, Antimicrobial Peptide, human 0.5 mg
SP2321b LL - 37, Antimicrobial Peptide, human
SP-54949-1 LL _ 37, Antimicrobial Peptide, human (AA Leu_Leu_Gly_Asp_Phe_Phe_Arg_Lys_Ser_Lys_Glu_Lys_Ile_Gly_Lys_Glu_Phe_Lys_Arg_Ile_Val_Gln_Arg_Ile_Lys_Asp_Phe_Leu_Arg_Asn_Leu_Val_Pro_Arg_Thr_Glu_Ser) (MW 449 1 mg
SP2321b LL - 37, Antimicrobial Peptide, human 1 mg
SP-54949-1 LL-37, Antimicrobial Peptide, human (AA: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser) (MW: 4493. 1 mg Product tipe: Pure Peptide
SP-54949-1 LL-37, Antimicrobial Peptide, human (AA: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser) (MW: 4493. 1 mg
11771-05021 Antimicrobial Peptide LL-37, human 150 ug
SIG15_HUMAN Pig ELISA Kit FOR Antimicrobial peptide NK-lysin 96T
EIAAB27290 Antimicrobial peptide NK-lysin,NKL,NKL,Pig,Sus scrofa
E02C0333 Rat Cathelicidin Antimicrobial Peptide ELISA 96T/kit
E02H0053 Rat Hepcidin Antimicrobial Peptide ELISA 96T/kit
RPR-405 Recombinant Human Cathelicidin Antimicrobial Peptide 2


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur