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Pubmed ID :29143340
Publication Date : //

K TASK-2 and KCNQ1-KCNE3 K channels are major players contributing to intestinal anion and fluid secretion.


K channels are important in intestinal epithelium as they ensure the ionic homeostasis and electrical potential of epithelial cells during anion and fluid secretion. Intestinal epithelium cAMP-activated anion secretion depends on the activity of the (also cAMP dependent) KCNQ1-KCNE3 K channel, but the secretory process survives after genetic inactivation of the K channel in the mouse. Here we use double mutant mice to investigate which alternative K channels come into action to compensate for the absence of KCNQ1-KCNE3 K channels. Our data establish that whilst Ca -activated K 3.1 channels are not involved, K two-pore domain TASK-2 K channels are major players providing an alternative conductance to sustain the intestinal secretory process. Work with double mutant mice lacking both TASK-2 and KCNQ1-KCNE3 channels nevertheless points to yet-unidentified K channels that contribute to the robustness of the cAMP-activated anion secretion process.

Authors : Julio-Kalajzić Francisca , Villanueva Sandra , Burgos Johanna , Ojeda Margarita , Cid L Pablo , Jentsch Thomas J , Sepúlveda Francisco V ,

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