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Pubmed ID :29150792
Publication Date : //

Correlation between MGMT promoter methylation and response to temozolomide-based therapy in neuroendocrine neoplasms: an observational retrospective multicenter study.


Temozolomide (TEM) based therapy has been reported being effective in the treatment of metastatic neuroendocrine neoplasms (NEN), with response rates ranging from 30 to 70%. Among patients affected by advanced glioblastoma or melanoma and treated with TEM, loss of tumoral O6-methylguanine DNA methyltransferase (MGMT) is correlated with improved survival. In NEN patients, the role of MGMT deficiency in predicting clinical outcomes of TEM treatment is still under debate.

Authors : Campana Davide , Walter Thomas , Pusceddu Sara , Gelsomino Fabio , Graillot Emmanuelle , Prinzi Natalie , Spallanzani Andrea , Fiorentino Michelangelo , Barritault Marc , Dall'Olio Filippo , Brighi Nicole , Biasco Guido ,

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