Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29167230
Publication Date : //

Absence of CD59 in Guinea Pigs: Analysis of theGenome Suggests the Evolution of aPseudogene.


CD59 is a membrane-bound regulatory protein that inhibits the assembly of the terminal membrane attack complex (C5b-9) of complement. From its original discovery in humans almost 30 years ago, CD59 has been characterized in a variety of species, from primates to early vertebrates, such as teleost fish. CD59 is ubiquitous in mammals; however, we have described circumstantial evidence suggesting that guinea pigs () lack CD59, at least on erythrocytes. In this study, we have used a combination of phylogenetic analyses with syntenic alignment of mammaliangenes to identify the only span of genomic DNA inthat is homologous to a portion of mammalianand show that this segment of DNA is not transcribed. We describe a pseudogene sharing homology to exons 2 through 5 of humanpresent in thegenome. This pseudogene was flanked byhomologs of two genes,and, a relationship and orientation that were consistent with other known mammaliangenes. Analysis using RNA sequencing confirmed that this segment of chromosomal DNA was not transcribed. We conclude that guinea pigs lack an intact gene encoding CD59; to our knowledge, this is the first report of a mammalian species that does not express a functional CD59. The pseudogene we describe is likely the product of a genomic deletion event during its evolutionary divergence from other members of the rodent order.

Authors : Boshra Hani , Zelek Wioleta M , Hughes Timothy R , Rodriguez de Cordoba Santiago , Morgan B Paul ,

Related products :

Catalog number Product name Quantity
PG2030 CD59 Monoclonal Antibodies for use in pigs Clone: MUC93A Ig isotype: G1
LF-MA40232 anti-CD59 Antigen P18-20 (CD59) (1F5), Mouse monoclonal to CD59 Antigen P18-20 (CD59), Isotype IgG1, Host Mouse 50 ug
26-639 RAB40B has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles.The protein encoded by this gene has similarity to a yeast protein which suggests a 0.05 mg
E05P0352 Guinea Protectin Elisa Kit (CD59) 96 Tests/kit
E05P0352 Guinea pig Protectin ELISA , CD59
E05P0352 Guinea anti-Protectin Elisa Kit (CD59) 96 Tests/kit
MCA3955Z MOUSE ANTI HUMAN PIGS Azide Free, Product Type Monoclonal Antibody, Specificity PIGS, Target Species Human, Host Mouse, Format Azide Free, Isotypes IgG2b, Applications WB, Clone 3F3 0.1 mg
TotalLabQuant Base package*: 1D image analysis plus colony counting and array analysis
AS-MRA-P5 MARIA™ ANALYSIS SERVICE 5-plex analysis Environmental Testing Services 1 sample
XGC-BiRDS-MeDIP-Seq Bioinformatics analysis of Methylome data for Methylation analysis Sample
AS-MRA-P8 MARIA™ ANALYSIS SERVICE 8-plex analysis Environmental Testing Services 1 sample
TotalLab Quant Base package* 1D image analysis plus colony counting and array analysis
TotalLab Quant Base package* 1D image analysis plus colony counting and array analysis 1
XGC-BiRDS-WGBS Bioinformatics analysis of Whole Genome Bisulphite Sequencing data for Methylation analysis Sample
Phoretix 1D  Base package* 1D image analysis with band pattern matching, plus colony counting and array analysis
Phoretix1D Base package*: 1D image analysis with band pattern matching, plus colony counting and array analysis
Phoretix 1D Base package* 1D image analysis with band pattern matching, plus colony counting and array analysis 1
A91336Rb01 Antibody to Protectin (CD59) Organism: Oryctolagus cuniculus (Rabbit) Type: Polyclonal Source: Guinea pig 100ug
A91336Rb01 Antibody to Protectin (CD59) Organism: Oryctolagus cuniculus (Rabbit) Type: Polyclonal Source: Guinea pig 50ug
29-712 ITGBL1 may be linked in some way with the evolution of the integrin beta subunits. 0.1 mg
AS-MRA-P5 8-plex analysis MARIA™ ANALYSIS SERVICE 1 sample
AS-MRA-P8 8-plex analysis MARIA™ ANALYSIS SERVICE 1 sample
1P-388-T100 Mouse Monoclonal to CD59 _ Protectin Antigen CD59 Isotype IgM Antigen CD59 Isotype IgM 100 tests
10-388-C025 Mouse Monoclonal to CD59 _ Protectin Antigen CD59 Isotype IgM Antigen CD59 Isotype IgM 0.025 mg
10-388-C100 Mouse Monoclonal to CD59 _ Protectin Antigen CD59 Isotype IgM Antigen CD59 Isotype IgM 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur