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Pubmed ID :29179175
Publication Date : //

Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.


Previous studies have shown that heat shock protein 90 (HSP90)-mediated mitochondrial import of connexin 43 (Cx43) is critical in preconditioning cardioprotection. The present study was designed to test whether postconditioning has the same effect as preconditioning in promoting Cx43 translocation to mitochondria and whether mitochondrial HSP90 modulates this effect.

Authors : Tu Rong-Hui , Li Qing-Jie , Huang Zheng , He Yan , Meng Jian-Jun , Zheng Hui-Lei , Zeng Zhi-Yu , Zhong Guo-Qiang ,

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