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Pubmed ID :29214179
Publication Date : //

The Roles of Thrombospondins in Hemorrhagic Stroke.


Hemorrhagic stroke is a devastating cerebrovascular disease with significant morbidity and mortality worldwide. Thrombospondins (TSPs), as matricellular proteins, belong to the TSP family which is comprised of five members. All TSPs modulate a variety of cellular functions by binding to various receptors. Recently, TSPs gained attention in the area of hemorrhagic stroke, especially TSP-1. TSP-1 participates in angiogenesis, the inflammatory response, apoptosis, and fibrosis after hemorrhagic stroke through binding to various molecules including but not limited to CD36, CD47, and TGF-. In this review, we will discuss the roles of TSPs in hemorrhagic stroke and focus primarily on TSP-1.

Authors : Wu Xuan , Luo Xu , Zhu Qiquan , Zhang Jie , Liu Yun , Luo Hansheng , Cheng Yuan , Xie Zongyi ,

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