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Pubmed ID :29221887
Publication Date : //

Resistance analysis in patients with genotype 1-6 HCV infection treated with sofosbuvir/velpatasvir in the phase III studies.


The fixed-dose combination of sofosbuvir/velpatasvir was highly efficacious in patients infected with genotype (GT)1-6 hepatitis C virus (HCV) in the ASTRAL studies. This analysis evaluated the impact of baseline resistance-associated substitutions (RASs) on treatment outcome and emergence of RASs in patients infected with HCV GT1-6 who were treated with sofosbuvir/velpatasvir.

Authors : Hezode Christophe , Reau Nancy , Svarovskaia Evguenia S , Doehle Brian P , Shanmugam Ragavi , Dvory-Sobol Hadas , Hedskog Charlotte , McNally John , Osinusi Anu , Brainard Diana M , Miller Michael D , Mo Hongmei , Roberts Stuart K , O'Leary Jacqueline G , Shafran Stephen D , Zeuzem Stefan ,

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