Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29226876
Publication Date : //

Serum C-Peptide, Visfatin, Resistin, and Ghrelin are Altered in Sporadic and GRN-Associated Frontotemporal Lobar Degeneration.


Frontotemporal lobar degeneration (FTLD) is a group of complex neurodegenerative disease characterized by progressive deterioration of the frontal and anterior temporal lobes of the brain resulting in different heterogeneous conditions, mainly characterized by personality changes, behavioral disturbances, such as binge eating, and deficits in language and executive functions. Null mutations in progranulin gene (GRN) are one of the most frequent genetic determinants in familial frontotemporal dementia. Recently, progranulin was recognized as an adipokine involved in diet-induced obesity and insulin resistance revealing its metabolic function. Increasing evidence suggests that neurodegenerative dementias are associated with a higher prevalence of metabolic changes than in the general population. According to these findings, the aim of this study is to investigate putative alterations in markers linked to metabolic functions (i.e., C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, glucagon, insulin, resistin, and three adipokines as visfatin, leptin, and plasminogen activator inhibitor-1 total) in sporadic and GRN-related FTLD. We found that 1) C-peptide is increased in sporadic and GRN-mutated FTLD patients; in addition, we demonstrated an anticipation of the disease in patients with the highest C-peptide concentrations; 2) visfatin is slightly reduced in the whole FTLD group; 3) resistin, an adipokine involved in inflammatory-related diseases, is specifically increased in FTLD due to GRN null mutations; 4) ghrelin concentration is specifically increased in pre-symptomatic subjects and FTLD patients with GRN mutations. These findings support the hypothesis that alterations in metabolic pattern are involved in FTLD progression highlighting novel putative targets for the development of preventive and personalized therapies.

Authors : Zanardini Roberta , Benussi Luisa , Fostinelli Silvia , Saraceno Claudia , Ciani Miriam , Borroni Barbara , Padovani Alessandro , Binetti Giuliano , Ghidoni Roberta ,

Related products :

Catalog number Product name Quantity
CSB-E09816r Rat growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit, Species Rat, Sample Type serum, plasma 96T
CSB-E09437p Pig growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit, Species Pig, Sample Type serum, plasma 96T
CSB-E09815h Human growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit, Species Human, Sample Type serum, plasma 96T
CSB-E09817m Mouse growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit, Species Mouse, Sample Type serum, plasma 96T
201-11-0554 Rat Growth Hormone Releasing Peptide-ghrelin,GHRP-ghrelin ELISA Kit 96T
E0553Ra Rat Growth Hormone Releasing Peptide-ghrelin,GHRP-ghrelin ELISA Kit 48T
UB-E11091 Rat Growth Hormone Releasing Peptide-ghrelin(GHRP-ghrelin)ELISA Kit 96T
201-11-0554 Rat Growth Hormone Releasing Peptide-ghrelin(GHRP-ghrelin)ELISA Kit 96T
E0553Ra Rat Growth Hormone Releasing Peptide-ghrelin,GHRP-ghrelin ELISA Kit 96T
YHB0519Ra Rat Growth Hormone Releasing Peptide-ghrelin,GHRP-ghrelin ELISA Kit 48T
KN0539Ra Rat growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit 96 WELLS
SL0328Ra Rat growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit 96T
QY-E11091 Rat Growth Hormone Releasing Peptide-ghrelin(GHRP-ghrelin)ELISA Kit 96T
CK-E30120 Rat growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit 96T
YHB0519Ra Rat Growth Hormone Releasing Peptide-ghrelin,GHRP-ghrelin ELISA Kit 96T
CK-E98155 Rat growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISAkit
E0552Ra Rat Growth Hormone Releasing Peptide-ghrelin,GHRP-ghrelin ELISA Kit 48T
21954 Rat Growth Hormone Releasing Peptide-Ghrelin(GHRP-Ghrelin) ELISA Kit 96T
RD172062100 Acylated Ghrelin (Ghrelin-28, Obestatin), Human synthetic peptide 0.1 mg
RD172062100 Human, Acylated Ghrelin (Ghrelin-28, Obestatin) , synthetic peptide 0.1 mg
SL0251Mo Mouse growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit 96T
E0248Po Porcine growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit 48T
201-12-0973 Human growth hormone releasing peptide-Ghrelin(GHRP-Ghrelin)ELISA Kit 96T
E0151Mo Mouse growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit 48T
HG050 Human growth hormone releasing peptide-Ghrelin,GHRP-Ghrelin ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur