Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29276985
Publication Date : //

Upregulation of miR-221 and -222 in response to increased extracellular signal-regulated kinases 1/2 activity exacerbates neointimal hyperplasia in diabetes mellitus.


Diabetes is associated with accelerated arterial intimal thickening that contributes to the increased cardiovascular disease seen in this population. In healthy arteries, intimal thickening is inhibited by elevated levels of the cyclin-dependent kinase inhibitor, p27, and intimal thickening is promoted by activation of the mammalian Target of Rapamycin to promote degradation of p27 protein. Recently, we reported that two microRNAs, miR-221 and -222, which promote intimal thickening via down-regulation of mRNA encoding p27, are elevated in the arteries of diabetic patients. To determine if these miRNAs are critical to the increased intimal thickening under diabetic conditions, we examined the regulation of p27in a mouse model of diabetes.

Authors : Lightell Daniel J , Moss Stephanie C , Woods T Cooper ,

Related products :

Catalog number Product name Quantity
EIAAB24877 ERK7,ERK-7,ERK8,ERK-8,Extracellular signal-regulated kinase 7,Extracellular signal-regulated kinase 8,Homo sapiens,Human,MAP kinase 15,MAPK 15,MAPK15,Mitogen-activated protein kinase 15
PY-10201 Signal transduction related antibodies: Anti- Extracellular signal-regulated kinase 1(ERK1),Chicken-Poly 100μg
PY-10188 Signal transduction related antibodies: Anti- Extracellular signal-regulated kinase 3(ERK3),Chicken-Poly 100μg
orb60627 Glipizide Glipizide(Glucotrol) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. For research use only. 500 mg
IDE IDDM9 Gene insulin-dependent diabetes mellitus 9
orb80740 Lypressin protein Lypressin is hormone used to prevent or control the frequent urination, increased thirst, and loss of water associated with diabetes insipidus (water diabetes). Its molecular weight 5 mg
E02E0171 Rat Extracellular Signal Regulated Kinase 96 Tests/kit
IDDM18 IDDM16 Gene insulin-dependent diabetes mellitus 16
IDDM17 IDDM15 Gene insulin-dependent diabetes mellitus 15
IDDM2 IDDM17 Gene insulin-dependent diabetes mellitus 17
IDDM23 IDDM18 Gene insulin-dependent diabetes mellitus 18
IDDM24 IDDM2 Gene insulin-dependent diabetes mellitus 2
IDDM6 IDDM3 Gene insulin-dependent diabetes mellitus 3
IDDM8 IDDM6 Gene insulin-dependent diabetes mellitus 6
IDDMX IDDM8 Gene insulin-dependent diabetes mellitus 8
IDDM16 IDDM14 Gene insulin-dependent diabetes mellitus 14
IDDM15 IDDM13 Gene insulin-dependent diabetes mellitus 13
IDDM9 IDDM7 Gene insulin-dependent diabetes mellitus 7
IDDM13 IDDM10 Gene insulin-dependent diabetes mellitus 10
IDDM7 IDDM4 Gene insulin-dependent diabetes mellitus 4
IDDM14 IDDM11 Gene insulin-dependent diabetes mellitus 11
E06E0171 Goat Extracellular Signal Regulated Kinase 96 Tests/kit
E12410822 Rat extracellular signal-regulated kinase(ERK) ELISA Kit 1
E02E0058 Rat Extracellular Signal Regulated Kinase 1 ELISA 96T/kit
E03E0171 Mouse Extracellular Signal Regulated Kinase 96 Tests/kit


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur