Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29297146
Publication Date : //

Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers.


Developing a system of molecular subtyping for endometrial tumors might improve insight into disease etiology and clinical prediction of patient outcomes. High body mass index (BMI) has been implicated in development of endometrial cancer through hormonal pathways and might influence tumor expression of biomarkers involved in BMI-sensitive pathways. We evaluated whether endometrial tumor expression of 7 markers from BMI-sensitive pathways of insulin resistance could effectively characterize molecular subtypes: adiponectin receptor 1, adiponectin receptor 2, leptin receptor, insulin receptor (beta subunit), insulin receptor substrate 1, insulin-like growth factor 1 receptor, and insulin-like growth factor 2 receptor. Using endometrial carcinoma tissue specimens from a case-only prospective sample of 360 women from the Nurses' Health Study, we scored categorical immunohistochemical measurements of protein expression for each marker. Logistic regression was used to estimate associations between endometrial cancer risk factors, especially BMI, and tumor marker expression. Proportional hazard modeling was performed to estimate associations between marker expression and time to all-cause mortality as well as time to endometrial cancer-specific mortality. No association was observed between BMI and tumor expression of any marker. No marker was associated with time to either all-cause mortality or endometrial cancer-specific mortality in models with or without standard clinical predictors of patient mortality (tumor stage, grade, and histologic type). It did not appear that any of the markers evaluated here could be used effectively to define molecular subtypes of endometrial cancer.

Authors : Busch Evan L , Crous-Bou Marta , Prescott Jennifer , Downing Michael J , Rosner Bernard A , Mutter George L , De Vivo Immaculata ,

Related products :

Catalog number Product name Quantity
Endometrium - EMC1501 Endometrial cancer array consists of duplicated 70 cases of endometrial cancer and 5 cases of normal and other non_malignant endometrial tissues. 1.1mm
Endometrium - EMC961 Endometrial cancer array consists of duplicated 36 cases of endometrial cancer and 12 cases of normal and other non_malignant endometrial tissues. 1.5mm
UT801 Endometrial disease spectrum (endometrial cancer progression) tissue array, 80 cases_80 cores
Z7020023 Endometrial Tumor Tissue Array - 12 cases of endometrial cancer paired with adjacent normal tissues
Z7020023 Endometrial Tumor Tissue Array - 12 cases of endometrial cancer paired with adjacent normal tissues 5 slides
Z7020023 Endometrial Tumor Tissue Array _ 12 cases of endometrial cancer paired with adjacent normal tissues 5 slides
Z7020023 Endometrial Tumor Tissue Array _ 12 cases of endometrial cancer paired with adjacent normal tissues 5 slides
UT801 Endometrial disease spectrum (endometrial cancer progression) tissue array, 80 cases_80 cores; ihc Anti-Actin confirmed
Z7020024 Endometrial Tumor Tissue Array - Duplicated 36 cases of endometrial cancer and 12 cases of normal and other non-malignan
Z7020022 Endometrial Tumor Tissue Array _ Duplicated 70 cases of endometrial cancer and 5 cases of normal and other non_malignan 5 slides
Z7020022 Endometrial Tumor Tissue Array - Duplicated 70 cases of endometrial cancer and 5 cases of normal and other non-malignan 5 slides
Z7020022 Endometrial Tumor Tissue Array - Duplicated 70 cases of endometrial cancer and 5 cases of normal and other non-malignan
Z7020024 Endometrial Tumor Tissue Array - Duplicated 36 cases of endometrial cancer and 12 cases of normal and other non-malignan 5 slides
Z7020024 Endometrial Tumor Tissue Array _ Duplicated 36 cases of endometrial cancer and 12 cases of normal and other non_malignan 5 slides
Z7020022 Endometrial Tumor Tissue Array _ Duplicated 70 cases of endometrial cancer and 5 cases of normal and other non_malignan 5 slides
Z7020024 Endometrial Tumor Tissue Array _ Duplicated 36 cases of endometrial cancer and 12 cases of normal and other non_malignan 5 slides
29-386 KHDRBS1 recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, KHDRBS1 functions as an adapter protein in signal 0.05 mg
Endometrium - EMC241 Endometrium cancer tissue array, 12 cases of endometrial cancer paired with corresponding uninvolved tissues from the same patients 2.5mm
EMC962-5 Human Endometrial Cancer tissue array 5x (8x12)
EMC1021 Endometrial cancer tissue array of 102 cases (1.5mm) 102 Cases
EMC1501-5 Human Endometrial Cancer tissue array 5x (10x15)
TS1057 Human endometrial cancer Tissue Section 1 slide
EMC2281 Endometrial cancer tissue array of 228 cases (1.1mm) 228 Cases
EMC962-1 Human Endometrial Cancer tissue array 1x (8x12)
EMC1501-1 Human Endometrial Cancer tissue array 1x (10x15)


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur