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Pubmed ID :29337141
Publication Date : //

Alterations of oxygen consumption and extracellular acidification rates by glutamine in PBMCs of SLE patients.


We evaluated plasma glutamine levels and basal mitochondrial oxygen consumption rate (mOCR) and basal extracellular acidification rate (ECAR) of peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematous (SLE) patients and healthy controls (HCs). Lower plasma glutamine levels correlated with higher SLE disease activity indexes (p=0.025). Incubated in DMEM containing 100mg/dL glucose, SLE-PBMCs displayed lower mOCR (p=0.018) but similar ECAR (p=0.467) to those of HC-PBMCs, and their mOCR got elevated (p<0.001) without altering ECAR (p=0.239) by supplementation with 2 or 4mM glutamine. We conclude that impaired mitochondrial respiration of SLE-PBMCs could be improved by glutamine under euglycemic condition.

Authors : Lee Hui-Ting , Lin Chen-Sung , Pan Siao-Cian , Wu Tsai-Hung , Lee Chyou-Shen , Chang Deh-Ming , Tsai Chang-Youh , Wei Yau-Huei ,

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