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Pubmed ID :29346407
Publication Date : //

Relaxin reverses inflammatory and immune signals in aged hearts.


'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive remodeling in aging and HF.

Authors : Martin Brian , Gabris-Weber Beth Ann , Reddy Rajiv , Romero Guillermo , Chattopadhyay Ansuman , Salama Guy ,

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