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Pubmed ID :29410097
Publication Date : //

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon.


Hepatitis C virus (HCV) infection is sensitive to interferon (IFN)-based therapy, whereas hepatitis B virus (HBV) infection is not. It is unclear whether HBV escapes detection by the IFN-mediated immune response or actively suppresses it. Moreover, little is known on how HBV and HCV influence each other in coinfected cells. We investigated interactions between HBV and the IFN-mediated immune response using HepaRG cells and primary human hepatocytes (PHHs). We analyzed the effects of HBV on HCV replication, and vice versa, at the single-cell level.

Authors : Mutz Pascal , Metz Philippe , Lempp Florian A , Bender Silke , Qu Bingqian , Schöneweis Katrin , Seitz Stefan , Tu Thomas , Restuccia Agnese , Frankish Jamie , Dächert Christopher , Schusser Benjamin , Koschny Ronald , Polychronidis Georgios , Schemmer Peter , Hoffmann Katrin , Baumert Thomas F , Binder Marco , Urban Stephan , Bartenschlager Ralf ,

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