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Pubmed ID :29448105
Publication Date : //

Casein kinase 2 phosphorylates and stabilizes C/EBPβ in pancreatic β cells.


During the development of type 2 diabetes, endoplasmic reticulum (ER) stress leads to pancreatic β cell failure. CCAAT/enhancer-binding protein (C/EBP) β is highly induced by ER stress and AMP-activated protein kinase (AMPK) suppression in pancreatic β cells, and its accumulation reduces pancreatic β cell mass. We investigated the phosphorylation state of C/EBPβ under these conditions. Casein kinase 2 (CK2) was found to co-localize with C/EBPβ in MIN6 cells. It phosphorylated S222 of C/EBPβ, a previously unidentified phosphorylation site. We found that C/EBPβ is phosphorylated by CK2 under AMPK suppression and ER stress, which are important from the viewpoint of the worsening pathological condition of type 2 diabetes, such as decreased insulin secretion and apoptosis of pancreatic β cells.

Authors : Takai Tomoko , Matsuda Tomokazu , Matsuura Yuki , Inoue Kaho , Suzuki Emi , Kanno Ayumi , Kimura-Koyanagi Maki , Asahara Shun-Ichiro , Hatano Naoya , Ogawa Wataru , Kido Yoshiaki ,

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