Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29527514
Publication Date : //

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy.


Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewis, Lewis, and sialyl Lewis) and type II (H2, Lewis, Lewis, and sialyl Lewis) Lewis antigens, frequently occurs on the cancer cell surface and is mainly attributed to upregulated expression of pertinent fucosyltransferases (FUTs). Nevertheless, the impact of fucose-containing moieties on tumor cell biology is not fully elucidated yet. Here, we review the relevance of tumor-overexpressed FUTs and their respective synthesized Lewis determinants in critical aspects associated with cancer progression, such as increased cell survival and proliferation, tissue invasion and metastasis, endothelial to mesenchymal transition, endothelial and immune cell interaction, angiogenesis, multidrug resistance, and cancer stemness. Furthermore, we discuss the potential use of enhanced levels of fucosylation as glycan biomarkers for early prognosis, diagnosis, and disease monitoring in cancer patients.

Authors : Blanas Athanasios , Sahasrabudhe Neha M , Rodríguez Ernesto , van Kooyk Yvette , van Vliet Sandra J ,

Related products :

Catalog number Product name Quantity
E7563h Human Tongue Cancer Chemotherapy Resistance Associ 96T
26-080 RRP1B belongs to the RRP1 family. It may be a novel susceptibility gene for breast cancer progression and metastasis. 0.05 mg
EIAAB13788 FAM168A,Homo sapiens,Human,KIAA0280,Protein FAM168A,TCRP1,Tongue cancer chemotherapy resistance-associated protein 1
orb60366 Isotretinoin It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. For research use only. 1 g
20-783-74648 MOUSE ANTI HUMAN BREAST CANCER RESISTANCE PROTEIN - Placenta-specific ATP-binding cassette transporter; Breast cancer resistance protein; Mitoxantrone resistance-associated protein; CD338 antigen; CDw 1 ml
GB-10010 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 8 (TEM8), Rabbit-Poly 100μg
GB-30131 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 2 (TEM2), Rabbit-Poly 100μg
GB-10009 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 8 (TEM8), Rabbit-Poly 100μg
GB-10344 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 8 (TEM8), Rabbit-Poly 250μl
GB-30088 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 5 (TEM5), Rabbit-Poly 100μg
GB-30028 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 5 (TEM5), Rabbit-Poly 100μg
GB-30021 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 8 (TEM8), Rabbit-Poly 250μl
GB-30115 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 8 (TEM8), Rabbit-Poly 100ug
GB-10011 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 5 (TEM5), Rabbit-Poly 250μl
GB-30113 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 8 (TEM8), Rabbit-Poly 100ug
GB-10374 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 1 (TEM1 or endosialin), Rabbit-Poly 100μg
GB-30132 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 3 (TEM3 or plexin domain containing 1 ), Rabbit-Poly 100μg
GB-30133 Cancer and metastasis related antibodies : Anti-Tumor endothelial marker 4 (TEM4 or Rho guanine nucleotide exchange factor (GEF) 17), Rabbit-Poly 100μg
27-427 GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in 0.05 mg
27-632 GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in 0.05 mg
PY-10034 Cancer and metastasis related antibodies : Anti-Breast cancer 1(BRCA1),Chicken-Poly 100μg
29-666 The down-regulation of C9orf127 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. However, it may not contribute to the development and progression of gastric carcin 0.05 mg
29-756 The down-regulation of C9orf127 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. However, it may not contribute to the development and progression of gastric carcin 0.1 mg
29-665 The down-regulation of C9orf127 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. However, it may not contribute to the development and progression of gastric carcin 0.05 mg
orb61241 Doxorubicin Doxorubicin is a drug used in cancer chemotherapy. For research use only. 100 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur