Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29577893
Publication Date : //

Participation of transient receptor potential vanilloid 1 in paclitaxel-induced acute visceral and peripheral nociception in rodents.


The clinical use of paclitaxel as a chemotherapeutic agent is limited by the severe acute and chronic hypersensitivity caused when it is administered via intraperitoneal or intravenous routes. Thus far, evidence has suggested that transient receptor potential vanilloid-1 (TRPV1) has a key role in the chronic neuropathy induced by paclitaxel. Despite this, the role of TRPV1 in paclitaxel -related acute nociception, especially the development of visceral nociception, has not been evaluated. Thus, the goal of this study was to evaluate the participation of TRPV1 in a model of acute nociception induced by paclitaxel in rats and mice. A single intraperitoneal (i.p.) paclitaxel administration (1 mg/kg, i.p.) produced an immediate visceral nociception response 1 h after administration, caused mechanical and heat hypersensitivity, and diminished burrowing behaviour 24 h after administration. These nociceptive responses were reduced by SB-366791 treatment (0.5 mg/kg, i.p., a TRPV1 antagonist). In addition, TRPV1-positive sensory fibre ablation (using resiniferatoxin, 200 µg/kg, s.c.) reduced visceral nociception and mechanical or heat hypersensitivity caused by paclitaxel injection. Similarly, TRPV1 deficient mice showed a pronounced reduction in mechanical allodynia to paclitaxel acute injection and did not develop heat hypersensitivity. Moreover, 24 h after its injection, paclitaxel induced chemical hypersensitivity to capsaicin (a TRPV1 agonist, 0.01 nmol/site) and increased TRPV1 immunoreactivity in the dorsal root ganglion and sciatic nerve. In conclusion, TRPV1 is involved in mechanical and heat hypersensitivity and spontaneous-pain behaviour induced 24 h after a single paclitaxel injection. This receptor is also involved in visceral nociception induced immediately after paclitaxel administration.

Authors : Rossato Mateus Fortes , Rigo Flavia Karine , Oliveira Sara Marchesan , Guerra Gustavo Petri , Silva Cássia Regina , Cunha Thiago Mattar , Gomez Marcus Vinícius , Ferreira Juliano , Trevisan Gabriela ,

Related products :

Catalog number Product name Quantity
EIAAB44124 Homo sapiens,Human,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential cation channel subfamily V member 4,Transient receptor potential protein 12,TRP12,TrpV4,TRPV4,Vanilloid receptor-like ch
EIAAB44113 Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Rat,Rattus norvegicus,Transient receptor potential cation channel subfamily V member 1,TrpV1,Trpv1,Vanilloid receptor 1,Vanilloid receptor type 1-lik
EIAAB44123 Mouse,Mus musculus,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential cation channel subfamily V member 4,Transient receptor potential protein 12,TRP12,Trp12,TrpV4,Trpv4,Vanilloid receptor-l
EIAAB44103 Long transient receptor potential channel 7,LTrpC7,LTrpC-7,Rat,Rattus norvegicus,Transient receptor potential cation channel subfamily M member 7,Transient receptor potential-phospholipase C-interacti
EIAAB44106 Homo sapiens,Human,Long transient receptor potential channel 6,LTrpC6,LTRPC6,LTrpC-6,Transient receptor potential cation channel subfamily M member 8,Transient receptor potential p8,TRPM8,TRPP8,Trp-p8
18-001-30066 Transient receptor potential cation channel subfamily M member 8 - Transient receptor potential-p8; Trp-p8; Long transient receptor potential channel 6; LTrpC6 Polyclonal 0.1 mg
EIAAB44105 Long transient receptor potential channel 6,LTrpC6,Ltrpc6,LTrpC-6,Mouse,Mus musculus,Transient receptor potential cation channel subfamily M member 8,Transient receptor potential p8,Trpm8,Trpp8,Trp-p8
EIAAB44104 Chak,Channel-kinase 1,Long transient receptor potential channel 7,LTrpC7,Ltrpc7,LTrpC-7,Mouse,Mus musculus,Transient receptor potential cation channel subfamily M member 7,Transient receptor potential
EIAAB44121 Homo sapiens,Human,Transient receptor potential cation channel subfamily V member 3,TrpV3,TRPV3,Vanilloid receptor-like 3,VRL-3
EIAAB44117 Capsaicin receptor,Homo sapiens,Human,Osm-9-like TRP channel 1,OTRPC1,Transient receptor potential cation channel subfamily V member 1,TrpV1,TRPV1,Vanilloid receptor 1,VR1
EIAAB44092 Long transient receptor potential channel 2,LTrpC2,Ltrpc2,LTrpC-2,Mouse,Mus musculus,Transient receptor potential cation channel subfamily M member 2,Transient receptor potential channel 7,TrpC7,Trpc7
EIAAB44114 Mouse,Mus musculus,Osm-9-like TRP channel 1,OTRPC1,Transient receptor potential cation channel subfamily V member 1,TrpV1,Trpv1,Vanilloid receptor 1
EIAAB44115 Oryctolagus cuniculus,Osm-9-like TRP channel 1,OTRPC1,Rabbit,Transient receptor potential cation channel subfamily V member 1,TrpV1,Trpv1,Vanilloid receptor 1
EIAAB44119 Homo sapiens,Human,Osm-9-like TRP channel 2,OTRPC2,Transient receptor potential cation channel subfamily V member 2,TrpV2,TRPV2,Vanilloid receptor-like protein 1,VRL,VRL-1
18-783-75531 RABBIT ANTI Trpv2 (N-TERMINAL) - TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL. SUBFAMILY V. MEMBER 2; TrpV2; osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1 Polyclonal 0.05 mg
EIAAB44120 Osm-9-like TRP channel 2,OTRPC2,Rat,Rattus norvegicus,Sac2b,Stretch-activated channel 2B,Transient receptor potential cation channel subfamily V member 2,TrpV2,Trpv2,Vanilloid receptor-like protein 1,
EIAAB44125 Osm-9-like TRP channel 4,OTRPC4,Rat,Rattus norvegicus,Transient receptor potential cation channel subfamily V member 4,TrpV4,Trpv4,Vanilloid receptor-related osmotically-activated channel,Vroac,VR-OAC
EIAAB44091 Homo sapiens,Human,Long transient receptor potential channel 1,LTrpC1,LTRPC1,Melastatin-1,MLSN,MLSN1,Transient receptor potential cation channel subfamily M member 1,TRPM1
EIAAB44094 Homo sapiens,Human,KIAA1616,Long transient receptor potential channel 3,LTrpC3,LTRPC3,LTrpC-3,Melastatin-2,MLSN2,Transient receptor potential cation channel subfamily M member 3,TRPM3
EIAAB44099 Long transient receptor potential channel 5,LTrpC5,Ltrpc5,LTrpC-5,MLSN1- and TRP-related gene 1 protein,Mouse,Mtr1,Mus musculus,Transient receptor potential cation channel subfamily M member 5,Trpm5
EIAAB44098 Homo sapiens,Human,Long transient receptor potential channel 5,LTrpC5,LTRPC5,LTrpC-5,MLSN1- and TRP-related gene 1 protein,MTR1,Transient receptor potential cation channel subfamily M member 5,TRPM5
EIAAB44093 EREG1,Estrogen-responsive element-associated gene 1 protein,Homo sapiens,Human,KNP3,Long transient receptor potential channel 2,LTrpC2,LTRPC2,LTrpC-2,Transient receptor potential cation channel subfam
18-272-195365 TRPM2 - Rabbit polyclonal to TRPM2; EC 3.6.1.13; Long transient receptor potential channel 2; LTrpC2; LTrpC-2; Transient receptor potential channel 7; TrpC7; Estrogen-responsive element-associated gen 0.05 mg
18-272-195364 TRPM2 - Rabbit polyclonal to TRPM2; EC 3.6.1.13; Long transient receptor potential channel 2; LTrpC2; LTrpC-2; Transient receptor potential channel 7; TrpC7; Estrogen-responsive element-associated gen 0.05 mg
EIAAB44090 Long transient receptor potential channel 1,LTrpC1,Ltrpc1,Melastatin-1,Mouse,Mus musculus,Transient receptor potential cation channel subfamily M member 1,Trpm1


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur