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Pubmed ID :29579325
Publication Date : //

A phase 2 study of the PARP inhibitor veliparib plus temozolomide in patients with heavily pretreated metastatic colorectal cancer.


Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors such as veliparib are potent sensitizing agents and have been safely combined with DNA-damaging agents such as temozolomide. The sensitizing effects of PARP inhibitors are magnified when cells harbor DNA repair defects.

Authors : Pishvaian Michael J , Slack Rebecca S , Jiang Wei , He A Ruth , Hwang Jimmy J , Hankin Amy , Dorsch-Vogel Karen , Kukadiya Divyesh , Weiner Louis M , Marshall John L , Brody Jonathan R ,

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