Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29615518
Publication Date : //

Structural basis for the preference of the phosphatase RLPH2 for tyrosine-phosphorylated substrates.


Despite belonging to the phosphoserine- and phosphothreonine-specific phosphoprotein phosphatase (PPP) family, -like phosphatase 2 (RLPH2) strongly prefers substrates bearing phosphorylated tyrosine residues. We solved the structures of RLPH2 crystallized in the presence or absence of sodium tungstate. These structures revealed the presence of a central domain that forms a binding site for two divalent metal ions that closely resembles that of other PPP-family enzymes. Unique structural elements from two flanking domains suggest a mechanism for the selective dephosphorylation of phosphotyrosine residues. Cocrystallization with the phosphate mimetic tungstate also suggests how positively charged residues that are highly conserved in the RLPH2 class form an additional pocket that is specific for a phosphothreonine residue located near the phosphotyrosine residue that is bound to the active site. Site-directed mutagenesis confirmed that this auxiliary recognition element facilitates the recruitment of dual-phosphorylated substrates containing a pTxpY motif.

Authors : Labandera Anne-Marie , Uhrig R Glen , Colville Keaton , Moorhead Greg B , Ng Kenneth K S ,

Related products :

Catalog number Product name Quantity
26-668 CANT1 belongs to the apyrase family.It is a calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. The enzyme has very low 0.05 mg
EIAAB33052 HCP,Hematopoietic cell protein-tyrosine phosphatase,Homo sapiens,Human,Protein-tyrosine phosphatase 1C,Protein-tyrosine phosphatase SHP-1,PTP1C,PTP-1C,PTPN6,SH-PTP1,Tyrosine-protein phosphatase non-re
EIAAB33026 Mouse,Mus musculus,Protein tyrosine phosphatase DPZPTP,Protein tyrosine phosphatase PTP-BL,Protein-tyrosine phosphatase RIP,Ptp14,PTP36,Ptpn13,Tyrosine-protein phosphatase non-receptor type 13
EIAAB33117 FMI,Homo sapiens,hPTP-J,Human,Pancreatic carcinoma phosphatase 2,PCP2,PCP-2,Protein-tyrosine phosphatase J,Protein-tyrosine phosphatase pi,Protein-tyrosine phosphatase receptor omicron,PTP pi,PTP-J,PT
EIAAB33107 PC12-PTP1,Protein-tyrosine phosphatase PCPTP1,Ptp,Ptprr,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase R,R-PTP-R,Tyrosine phosphatase CBPTP
EIAAB32049 Macrophage actin-associated tyrosine-phosphorylated protein,Mayp,Mouse,Mus musculus,PEST phosphatase-interacting protein 2,pp37,Proline-serine-threonine phosphatase-interacting protein 2,Pstpip2
10-782-55086 Tyrosine-protein phosphatase non-receptor type 6 - EC 3.1.3.48; Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1 N_ 0.02 mg
PP-SHP1-020 SHP-1, Tyrosine-protein phosphatase non-receptor type 6, EC 3.1.3.48, Protein-tyrosine phosphatase 1C, PTP-1C, Hematopoietic cell protein-tyrosine phosphatase, SH-PTP1, Protein-tyrosine phosphatase SH 20
10-782-55086 Tyrosine-protein phosphatase non-receptor type 6 - EC 3.1.3.48; Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1 N_ 0.01 mg
10-782-55086 Tyrosine-protein phosphatase non-receptor type 6 - EC 3.1.3.48; Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1 N_ 0.005 mg
10-782-55086 Tyrosine-protein phosphatase non-receptor type 6 - EC 3.1.3.48; Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1 N_ 0.001 mg
EIAAB33050 Homo sapiens,Human,Neural-specific protein-tyrosine phosphatase,PTPN5,STEP,Striatum-enriched protein-tyrosine phosphatase,Tyrosine-protein phosphatase non-receptor type 5
EIAAB33022 Homo sapiens,Human,Protein-tyrosine phosphatase 1D,Protein-tyrosine phosphatase 2C,PTP-1D,PTP2C,PTP-2C,PTPN11,Shp2,SHP-2,SHPTP2,SH-PTP2,SH-PTP3,Tyrosine-protein phosphatase non-receptor type 11
EIAAB33119 Embryonic stem cell protein-tyrosine phosphatase,ES cell phosphatase,Esp,Osteotesticular protein-tyrosine phosphatase,OST-PTP,Ptprv,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase V,R
EIAAB43480 BM-008,Homo sapiens,Human,HU-PP-1,OV-1,PRL2,PRL-2,Protein tyrosine phosphatase type IVA 2,Protein-tyrosine phosphatase 4a2,Protein-tyrosine phosphatase of regenerating liver 2,PTP(CAAXII),PTP4A2,PTPCA
EIAAB33049 Neural-specific protein-tyrosine phosphatase,Ptpn5,Rat,Rattus norvegicus,STEP,Striatum-enriched protein-tyrosine phosphatase,Tyrosine-protein phosphatase non-receptor type 5
EIAAB33048 Mouse,Mus musculus,Neural-specific protein-tyrosine phosphatase,Ptpn5,STEP,Striatum-enriched protein-tyrosine phosphatase,Tyrosine-protein phosphatase non-receptor type 5
EIAAB33053 70Z-SHP,Hcp,Hcph,Hematopoietic cell protein-tyrosine phosphatase,Mouse,Mus musculus,Protein-tyrosine phosphatase 1C,Ptp1C,PTP-1C,Ptpn6,PTPTY-42,SHP-1,SH-PTP1,Tyrosine-protein phosphatase non-receptor
EIAAB43476 Homo sapiens,Human,PRL1,PRL-1,Protein tyrosine phosphatase type IVA 1,Protein-tyrosine phosphatase 4a1,Protein-tyrosine phosphatase of regenerating liver 1,PTP(CAAXI),PTP4A1,PTPCAAX1
29-723 SLC1A5 has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and bra 0.1 mg
EIAAB33056 Hematopoietic protein-tyrosine phosphatase,HEPTP,Lcptp,Protein-tyrosine phosphatase LC-PTP,Ptpn7,Rat,Rattus norvegicus,Tyrosine-protein phosphatase non-receptor type 7
EIAAB43483 Homo sapiens,Human,PRL3,PRL-3,PRL-R,Protein tyrosine phosphatase type IVA 3,Protein-tyrosine phosphatase 4a3,Protein-tyrosine phosphatase of regenerating liver 3,PTP4A3
EIAAB33054 Hematopoietic protein-tyrosine phosphatase,HEPTP,Homo sapiens,Human,Protein-tyrosine phosphatase LC-PTP,PTPN7,Tyrosine-protein phosphatase non-receptor type 7
10-663-45543 SHP-1 Protein tyrosine phosphatase Human - EC 3.1.3.48; Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1 N_A 0.005 mg
10-663-45543 SHP-1 Protein tyrosine phosphatase Human - EC 3.1.3.48; Protein-tyrosine phosphatase 1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; SH-PTP1; Protein-tyrosine phosphatase SHP-1 N_A 0.02 mg


https://antibody-antibodies.com/ | https://gentaur.com/ | https://gen-script.com/ | https://diagenox.com/ | https://clonagen.com/ | http://gentaursearch.com/ | http://gentaurpub.com/ | https://gentaur-online.com/ | http://anti-anti-pdf.com/ | http://gentaur-worldwide.com/

 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur

RSS Feeds · Most Popular · Today's Favorites · All Time Favorites · Gentaur Policy
© Copyright 2010-2011 GENTAUR molecular products.