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Pubmed ID :29635390
Publication Date : //

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.


BRCA1 and BRCA2 (BRCA1/2)-deficient tumors display impaired homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents or to poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi). Their efficacy in germline BRCA1/2 (gBRCA1/2)-mutated metastatic breast cancers has been recently confirmed in clinical trials. Numerous mechanisms of PARPi resistance have been described, whose clinical relevance in gBRCA-mutated breast cancer is unknown. This highlights the need to identify functional biomarkers to better predict PARPi sensitivity.

Authors : Cruz C , Castroviejo-Bermejo M , Gutiérrez-Enríquez S , Llop-Guevara A , Ibrahim Y H , Gris-Oliver A , Bonache S , Morancho B , Bruna A , Rueda O M , Lai Z , Polanska U M , Jones G N , Kristel P , de Bustos L , Guzman M , Rodríguez O , Grueso J , Montalban G , Caratú G , Mancuso F , Fasani R , Jiménez J , Howat W J , Dougherty B , Vivancos A , Nuciforo P , Serres-Créixams X , Rubio I T , Oaknin A , Cadogan E , Barrett J C , Caldas C , Baselga J , Saura C , Cortés J , Arribas J , Jonkers J , Díez O , O'Connor M J , Balmaña J , Serra V ,

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