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Pubmed ID :29661250
Publication Date : //

Isocitrate dehydrogenase 1-snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability.


The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. However, the expression levels of the IDH protein and their biological function in human breast cancer remain largely unknown.

Authors : Liu Wen-Shan , Chan Shih-Hsuan , Chang Hong-Tai , Li Guan-Cheng , Tu Ya-Ting , Tseng Hui-Hwa , Fu Ting-Ying , Chang Hui-Yu , Liou Huei-Han , Ger Luo-Ping , Tsai Kuo-Wang ,

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