Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29662631
Publication Date : //

Overlap at the molecular and immunohistochemical levels between angioimmunoblastic T-cell lymphoma and a subgroup of peripheral T-cell lymphomas without specific morphological features.


The overlap of morphology and immunophenotype between angioimmunoblastic T-cell lymphoma (AITL) and other nodal peripheral T-cell lymphomas (n-PTCLs) is a matter of current interest whose clinical relevance and pathogenic background have not been fully established. We studied a series of 98 n-PTCL samples (comprising 57 AITL and 41 PTCL-NOS) with five T antibodies (CD10, BCL-6, PD-1, CXCL13, ICOS), looked for mutations in five of the genes most frequently mutated in AITL (, and ) using the Next-Generation-Sequencing Ion Torrent platform, and measured the correlations of these characteristics with morphology and clinical features. The percentage of mutations in the and genes was similar (23.5% of cases). was mutated in 14.3%, in 11.2% and in 7.1% of cases, respectively. In the complete series, mutations in gene were associated with the presence of mutations in and ( 0.001, 0.043, and 0.029, respectively). Fourteen cases featured mutations without mutations. A close relationship was found between the presence of these mutations and a T-phenotype in AITL and PTCL-NOS patients. Interestingly, BCL-6 expression was the only T marker differentially expressed between AITL and PTCL-NOS cases. There were many fewer mutated cases than there were cases with a T phenotype. Overall, these data suggest alternative ways by which neoplastic T-cells overexpress these proteins. On the other hand, no clinical or survival differences were found between any of the recognized subgroups of patients with respect to their immunohistochemistry or mutational profile.

Authors : Manso Rebeca , González-Rincón Julia , Rodríguez-Justo Manuel , Roncador Giovanna , Gómez Sagrario , Sánchez-Beato Margarita , Piris Miguel A , Rodríguez-Pinilla Socorro M ,

Related products :

Catalog number Product name Quantity
'CS20-00-002 Human Lymphoma tissue array (Diffuse large cell B-cell T-cell Hodgkin lymphoma follicular diffuse B-cell, etc.) tissues 7 x 9
25-162 PARP9 contains 2 Macro domains and 1 PARP catalytic domain. PARP9 is overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk 0.05 mg
'CS20-00-003 Human Lymphoma tissue array (Plasmacytic lymphoma B-cell Large B-cell Burkitts lymphoma T-lymphoblastoma, etc.) tissues 7 x 9
LF-PA0178 anti-Bcl-2(B cell lymphoma 2), Rabbit polyclonal to Bcl-2(B cell lymphoma 2), Isotype IgG, Host Rabbit 100 ul
PM-117 H4134 Forward primer for overlap extension PCR (for LEXSY cell-free protein expression kit) 0,5nmol
PM-117 H4134 Forward primer for overlap extension PCR(for LEXSY cell-free protein expression kit) 0,5nmol
PC-FALP Fat cell-specific low molecular weight Protein Antibodies , WB control 100-150ul
FRAXA FRAT1 Gene frequently rearranged in advanced T-cell lymphomas
FRAXB FRAT2 Gene frequently rearranged in advanced T-cell lymphomas 2
PM-117 Nucleic acids: H4134 Forward primer for overlap extension PCR(for LEXSY cell-free protein expression kit) 0,5nmol
P-FALP110 Fat cell-specific low molecular weight Protein Antibodies , Antigen blocking peptide 100ul
P-FALP100 Fat cell-specific low molecular weight Protein Antibodies , Antigen blocking peptide 100ul
EIAAB25352 Falp,Fat cell-specific low molecular weight protein,Fat tissue-specific low MW protein,Melanocortin-2 receptor accessory protein,Mouse,Mrap,Mus musculus
EIAAB25353 B27,C21orf61,FALP,Fat cell-specific low molecular weight protein,Fat tissue-specific low MW protein,Homo sapiens,Human,Melanocortin-2 receptor accessory protein,MRAP
HTS-11603 Human Leukemias Lymphomas Tissue Slide (Lymphoma) (5 slides pk) 1 pk
Lymphoma - LYM181 5 types of 14 cases of various lymphomas from 7 nodal and extranodal sites. 2.5mm
FALP-101AP Fat cell-specific low molecular weight Protein Antibodies , Host species: Rabbit, Polyclonal antibody 200ul
FALP-112AP Fat cell-specific low molecular weight Protein Antibodies , Host species: Rabbit, Polyclonal antibody 200ul
27-497 CGI-143 encodes proteins that seem to be involved in cell proliferation or cell-cycle regulation, but the molecular function is still unknown. 0.05 mg
orb80956 Human B-Cell Lymphoma Protein Alpha His tag protein Bcl2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing amino acids 1-211 and having a molecular mass o 5
FALP-101AP Fat cell-specific low molecular weight Protein Antibodies Polyclonal anbtibody Host: Rabbit Affinity purifed 200ul
FALP-101AP Polyclonal Antibody Fat cell-specific low molecular weight Protein Antibodies Immunogen: peptide Host: Rabbit 200ul
FALP-112AP Polyclonal Antibody Fat cell-specific low molecular weight Protein Antibodies Immunogen: peptide Host: Rabbit 200ul
32-129 The CD19 antigen (95kDa) is expressed from the earliest stage of B progenitor development, on all peripheral B cells including germinal centre B cells, and all B cell lines and B cell leukaemia tested 0.1 mg
Z7020071 Lymphoma Tissue Array - 5 types of 14 cases of various lymphomas from 7 nodal and extranodal sites. 5 slides


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur