Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29669285
Publication Date : //

KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners.


Regulatory T cells (Tregs) are indispensable for the establishment of tolerance of self-antigens in animals. The transcriptional regulator Foxp3 is critical for Treg development and function, controlling the expression of genes important for Tregs through interactions with binding partners. We previously reported KAP1 as a binding partner of FOXP3 in human Tregs, but the mechanisms by which KAP1 affects Treg function were unclear. In this study, we analyzed mice with Treg-specific deletion of KAP1 and found that they develop spontaneous autoimmune disease. KAP1-deficient Tregs failed to induce Foxp3-regulated Treg signature genes. In addition, KAP1-deficient Tregs were less proliferative due to the decreased expression of Slc1a5, whose expression was KAP1 dependent but Foxp3 independent. This reduced expression of Slc1a5 resulted in reduced mTORC1 activation. Thus, our data suggest that KAP1 regulates Treg function in a Foxp3-dependent manner and also controls Treg proliferation in a Foxp3-independent manner.

Authors : Tanaka Shigeru , Pfleger Christian , Lai Jen-Feng , Roan Florence , Sun Shao-Cong , Ziegler Steven F ,

Related products :

Catalog number Product name Quantity
32-157 The transcription factor Foxp family includes Foxp1, Foxp2, and Foxp3. The Foxp3 (50KDa)plays a key role in CD4(+) CD25(+) regulatory T cell function and represents a specific marker for these cells. 0.1 mg
32-158 The transcription factor Foxp family included Foxp1, Foxp2, and Foxp3. The Foxp3(50KDa)played a key role in CD4(+) CD25(+) regulatory T cell function and represents a specific marker for these cells. 0.1 mL
orb84821 IL4 protein Interleukin4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone ma 10
orb84786 IL4 protein Interleukin4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone ma 20
orb82806 Mouse IL4 protein Interleukin-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and 1 mg
28-998 CNOT7 binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti 0.05 mg
27-497 CGI-143 encodes proteins that seem to be involved in cell proliferation or cell-cycle regulation, but the molecular function is still unknown. 0.05 mg
30-670 Putative function of SPATA12 is to maintain the cell in a differentiated state and_or to suppress cell proliferation in the human testis. 0.05 mg
27-784 ARID4A encodes a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription 0.1 mg
27-057 IL15 is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin 0.05 mg
27-499 DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a 0.1 mg
27-500 DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a 0.1 mg
30-268 NPDC1 suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. It might be involved in transcriptional regulation. 0.1 mg
orb82720 Human IL15 protein Interleukin 15 (IL15) regulates T and natural killer cell activation and proliferation. IL15and IL2 share many biological activities. They are found to bind common hematopoietinrece 1 mg
28-501 MOV10 may be an helicase with an important function in development and_or control of cell proliferation. 0.1 mg
30-561 TRAF3IP3 may function as an adapter molecule that regulates TRAF3-mediated JNK activation. 0.05 mg
orb82694 Human EPO Fc tag protein Erythropoietin (EPO), a glycoprotein produced primarily by the kidney, is the principalfactor that regulates erythropoiesis by stimulating the proliferation and differentiatio 1 mg
orb93585 EPO enzyme Erythropoietin (EPO), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroi 2000 IU
28-038 AF6 is a Ras target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL in leukemias caused by t (6;11) translocations. 0.1 mg
EIAAB06365 CDK5 activator 1,CDK5R,CDK5R1,Cyclin-dependent kinase 5 activator 1,Cyclin-dependent kinase 5 regulatory subunit 1,Homo sapiens,Human,NCK5A,TPKII regulatory subunit
EIAAB06364 Bos taurus,Bovine,CDK5 activator 1,CDK5R,CDK5R1,Cyclin-dependent kinase 5 activator 1,Cyclin-dependent kinase 5 regulatory subunit 1,NCK5A,TPKII regulatory subunit
EIAAB06363 CDK5 activator 1,Cdk5r,Cdk5r1,Cyclin-dependent kinase 5 activator 1,Cyclin-dependent kinase 5 regulatory subunit 1,Mouse,Mus musculus,Nck5a,TPKII regulatory subunit
29-852 DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and 0.05 mg
E2222h Homo sapiens,Human,Natural killer cell-enhancing factor A,NKEF-A,PAG,PAGA,PAGB,Peroxiredoxin-1,PRDX1,Proliferation-associated gene protein,TDPX2,Thioredoxin peroxidase 2,Thioredoxin-dependent peroxide
E2222h ELISA Homo sapiens,Human,Natural killer cell-enhancing factor A,NKEF-A,PAG,PAGA,PAGB,Peroxiredoxin-1,PRDX1,Proliferation-associated gene protein,TDPX2,Thioredoxin peroxidase 2,Thioredoxin-dependent pe 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur