Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29672582
Publication Date : //

Changes in N-glycans of IgG4 and its relationship with the existence of hypocomplementemia and individual organ involvement in patients with IgG4-related disease.


Although increased serum IgG4 level and tissue infiltration of IgG4-positive cells are key events in IgG4-related disease (IgG4RD), and nearly half of IgG4RD patients show hypocomplementemia, the role of IgG4 in the pathogenesis of IgG4RD remains unclear. Many reports show that altered IgG glycosylation, especially IgG with agalactosylated N-linked glycan (G0 N-glycan), have proinflammatory roles including complement activation, implicated in the pathogenesis of various inflammatory diseases. This study determined the concentration of N-linked glycans (N-glycan) released from serum IgG4 in IgG4RD patients and compared the difference of glycosylation changes to those in healthy controls. We also compared the concentration of each IgG4 glycoform between patients with and without hypocomplementemia and individual organ involvement (kidney, pancreas, lymph node) in IgG4RD.

Authors : Konno Naoki , Sugimoto Mitsuru , Takagi Tadayuki , Furuya Makiko , Asano Tomoyuki , Sato Shuzo , Kobayashi Hiroko , Migita Kiyoshi , Miura Yoshiaki , Aihara Taichi , Komatsuda Atsushi , Ohira Hiromasa , Watanabe Hiroshi ,

Related products :

Catalog number Product name Quantity
orb22278 Mouse Mab Against Human IgG4 Monoclonal Biotin-conjugated purified monoclonal mouse antibody to human IgG4, subclass specific. To identify the presence of IgG4 in human serum, other body fluids, cell 0.2 mg
orb22214 Mouse Ascites Against Human IgG4 Monoclonal Monoclonal mouse antibody to human IgG4, subclass specific. To identify the presence of IgG4 in human serum, other body fluids, cell and tissue substrates a 0.5 mg
orb22280 Mouse Mab Against Human IgG4 Monoclonal Peroxidase conjugated purified monoclonal mouse antibody to human IgG4, subclass specific. To identify the presence of IgG4 in human serum, other body fluids, c 0.2 mg
orb22279 Mouse Mab Against Human IgG4 Monoclonal Fluorescein isothiocyanate-conjugated purified monoclonal mouse antibody to human IgG4, subclass specific. To identify the presence of IgG4 in human serum, othe 0.2 mg
orb22277 Mouse Mab Against Human IgG4 Monoclonal Monoclonal mouse antibody to human IgG4, subclass specific. To identify the presence of IgG4 in human serum, other body fluids, cell and tissue substrates and t 0.2 mg
orb22281 Mouse Mab Against Human IgG4 Monoclonal Tetramethylrhodamine isothiocyanate-conjugated purified monoclonal mouse antibody to human IgG4, subclass specific. To identify the presence of IgG4 in human se 0.2 mg
MAHu/IgG4/Bio mouse MAb against human IgG4 (pFc subclass specific), conjugated with Biotin 0.2 mg
ShAHu/IgG4 sheep serum against human IgG4 (subclass specific) 1 ml
CH-3 Mouse anti-Der p 2 per human IgG4 (2B12-IgG4) Chimeric Antibodie 500
MAHu/IgG4 mouse ascites against human IgG4 (pFc subclass specific) 0.5 mg
MAHu/IgG4/PO mouse MAb against human IgG4 (pFc subclass specific), conjugated with Horseradish peroxidase 0.2 mg
orb22127 Human IgG4 Kappa Gm4A Chromatographically purified human myeloma IgG4 kappa, allotype Gm4b. Purified human IgG4 kappa may be used as a reference antigen, calibrator, coating protein and blocking agen 0.5 mg
MAHu/IgG4/MAb (1 mg) mouse MAb against human IgG4 (pFc subclass specific) 1 mg
MAHu/IgG4/MAb(1mg) mouse MAb against human IgG4 (pFc subclass specific) 1 mg
MAHu/IgG4/MAb mouse MAb against human IgG4 (pFc subclass specific) 0.2 mg
CH-3 Mouse anti-Der p 2-human IgG4 (2B12-IgG4) 500
CH-3 Mouse anti-Der p 2 per human IgG4 (2B12-IgG4) 500
DL-IgG4-Hu Human Immunoglobulin G4 (IgG4) ELISA Kit 96T
orb22126 Human IgG4 Kappa Gm4A Chromatographically purified human myeloma IgG4 kappa, allotype Gm4a. Purified human IgG4 kappa may be used as a reference antigen, calibrator, coating protein and blocking agen 0.5 mg
ILE-SCG80 Food IgG4 ELISA 2 Specific IgG4 MultiScreen, Nutritional, 1x 88 food antigens 1
MAHu/IgG4/FITC mouse MAb against human IgG4 (pFc subclass specific), conjugated with FITC 0.2 mg
ILE-SCG06 Food IgG4 ELISA 2 Specific IgG4 Screening, Nutritional, 4x 20 food antigens 1
ILE-SCG210 Food IgG4 ELISA 2 Specific IgG4 Screening, Nutritional, 3x 24 food antigens 1
MAHu/IgG4/TRITC mouse MAb against human IgG4 (pFc subclass specific), conjugated with TRITC 0.2 mg
SCH-5254-3004 NATIVE HUMAN IgG4, Product Type Antigen, Specificity IgG4, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur