Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
GM-CSF and IL-4 are not involved in IVIG-mediated amelioration of ITP in mice: a role for IL-11 cannot be ruled out.
Previously, we have reported that interleukin (IL)-4, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-11, but not IL-33, are up-regulated in two strains of mice with immune thrombocytopenia (ITP) that are responsive to intravenous immunoglobulin (IVIg) treatment. Previously, IL-4 was ruled out in the mechanism of IVIg; however, other publications have suggested this cytokine as a major player in the mechanism of IVIg action. Thus, we sought to further investigate a role for IL-4 and, in addition, GM-CSF and IL-11 in the mechanism of action of IVIg using a murine model of ITP. A passive platelet antibody model was used to generate ITP in IL-4 receptor knock-out (IL-4R ), IL-11 receptor knock-out (IL-11Rα ) and GM-CSF knock-out (Csf2 ) mice. We also used a neutralizing antibody to IL-11 and recombinant human IL-11 (rhIL-11) in addition to depleting basophils in vivo to study the effect of IVIg to ameliorate ITP. Our results showed that basophils, IL-4 and GM-CSF were unimportant in both ITP induction and its amelioration by IVIg. The role of IL-11 in these processes was less clear. Even though IL-11Rα mice with ITP responded to IVIg similarly to wild-type (WT) mice, treatment of ITP WT mice with rhIL-11 instead of IVIg showed an increase in platelet numbers and WT mice administered anti-IL-11 showed a significant reduction in the ability of IVIg to ameliorate the ITP. Our findings indicate that neither IL-4, basophils or GM-CSF have roles in IVIg amelioration of ITP; however, a role for IL-11 requires further study.
Authors : Lewis B J B , Leontyev D , Neschadim A , Blacquiere M , Branch D R ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
email@example.com | Gentaur | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
WP1069: Integrin-mediated cell adhesion
WP1185: Integrin-mediated cell adhesion
WP1386: Integrin-mediated cell adhesion
WP1545: miRNAs involved in DDR
WP1780: ABC-family proteins mediated transport
WP1782: APC/C-mediated degradation of cell cycle proteins
WP1815: Factors involved in megakaryocyte development and platelet production
WP1826: GPVI-mediated activation cascade
WP1845: MAPK targets/ Nuclear events mediated by MAP kinases
WP185: Integrin-mediated cell adhesion
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP1922: SLC-mediated transmembrane transport
WP2085: miRNAs involved in DDR
WP2292: Chemokine signaling pathway
WP6: Integrin-mediated cell adhesion
WP632: Cholesterol metabolism
WP74: Integrin-mediated cell adhesion
WP832: Integrin-mediated cell adhesion
WP951: Integrin-mediated cell adhesion
Related Genes :
 Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells.
 Post-traumatic stress disorder and serum cytokine and chemokine concentrations in patients with rheumatoid arthritis.
 Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline.
 One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis.
 Transcriptional profiles of cytokines and chemokines reveal important pro-inflammatory response from endothelial cells during Orientia tsutsugamushi infection.
 Identification of new urinary risk markers for urinary stones using a logistic model and multinomial logit model.
 Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation.
 Immunogenicity and protective efficacy of a new Leishmania hypothetical protein applied as a DNA vaccine or in a recombinant form against Leishmania infantum infection.
 Activation of the immune-inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis.
 In vitro and in vivo immunomodulatory effects of fucoidan compound agents.
Enter catalog number :