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Pubmed ID :29732722
Publication Date : //

Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid.


Neural tube defects (NTDs) are clinically significant congenital malformations which are known to be folic acid (FA) responsive, such that supplementation significantly reduces the prevalence of NTDs. Nonetheless, some individuals fail to respond to FA supplementation; hence NTDs remain a significant public health concern. The mechanisms that underlie the beneficial effects of FA supplementation remain poorly understood. Mouse models have been used extensively to study the mechanisms driving neural tube closure (NTC).

Authors : Gao Xiaoya , Finnell Richard H , Wang Hongyan , Zheng Yufang ,

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