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Pubmed ID :29735569
Publication Date : //

Isavuconazole Concentration in Real-world Practice: Consistency with Results from Clinical Trials.


Clinical use of voriconazole, posaconazole, and itraconazole revealed the need for therapeutic drug monitoring (TDM) of plasma concentrations of these antifungal agents. This need for TDM was not evident from clinical trials of these drugs. In order to establish if this requirement also applies to isavuconazole, we examined the plasma concentrations of 283 samples receiving isavuconazole in clinical practice and compared the values to those from clinical trials. The concentration distributions from real-world use and clinical trials were nearly identical (>1 μg/mL in 90% of patients). These findings suggest that routine TDM may not be required for isavuconazole in most instances.

Authors : Andes David , Kovanda Laura , Desai A , Kitt Theresa , Zhao M , Walsh Thomas J ,

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