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Pubmed ID :29751771
Publication Date : //

Unique and shared inflammatory profiles of human brain endothelia and pericytes.


Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of inflammation-related studies in endothelia and pericytes have been carried out using immortalised cell lines or non-human-derived cells. Whether these are representative of primary human cells is unclear and systematic comparisons of the inflammatory responses of primary human brain-derived pericytes and endothelia has yet to be performed.

Authors : Smyth Leon C D , Rustenhoven Justin , Park Thomas I-H , Schweder Patrick , Jansson Deidre , Heppner Peter A , O'Carroll Simon J , Mee Edward W , Faull Richard L M , Curtis Maurice , Dragunow Mike ,

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