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Pubmed ID :29757911
Publication Date : //

Caspase Inhibition During Cold Storage Improves Graft Function and Histology in a Murine Kidney Transplant Model.


Prolonged cold ischemia is a risk factor for delayed graft function of kidney transplants, and is associated with caspase-3-mediated apoptotic tubular cell death. We hypothesized that treatment of tubular cells and donor kidneys during cold storage with a caspase inhibitor before transplant would reduce tubular cell apoptosis and improve kidney function after transplant.

Authors : Nydam Trevor L , Plenter Robert , Jain Swati , Lucia Scott , Jani Alkesh ,

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