Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29777589
Publication Date : //

Low-adhesive ethylene vinyl alcohol-based packaging to xenogeneic islet encapsulation for type 1 diabetes treatment.

Transplantation of encapsulated porcine islets is proposed to treat type 1 diabetes. However, the envelopment of fibrous tissue and the infiltration of immune cells impair islet function and eventually cause implant failure. It is known that hemodialysis using an ethylene vinyl alcohol (EVOH) membrane results in minor tissue responses. Therefore, we hypothesized that using a low-adhesive EVOH membrane for encapsulation may prevent host cell accumulation and fibrous capsule formation. In this study, rat islets suspended in chitosan gel were encapsulated in bags made from highly porous EVOH membranes, and their in vitro insulin secretion function as well as in vivo performance was evaluated. The results showed that the EVOH bag did not affect islet survival or glucose-stimulated insulin secretion. Whereas naked islets were dysfunctional after 7 days of culture in vitro, islets within the EVOH bag produced insulin continuously for 30 days. Streptozotocin-induced diabetic mice were given islets-chitosan gel-EVOH implants intraperitoneally (650-800 islets equivalent) and exhibited lower blood glucose levels and regained body weight during a 4-week observation period. The transplanted mice had higher levels of serum insulin and C-peptide, with an improved blood glucose disappearance rate. Retrieved implants had minor tissue adhesion, and histology showed a limited number of mononuclear cells and fibroblasts surrounding the implants. No invasion of host cells into the EVOH bags was noticed, and the encapsulated islets were intact and positive for insulin-glucagon immunostaining. In conclusion, an EVOH bag can protect encapsulated islets, limit fibrous capsule formation, and extend graft function.

Authors : Yang Kai-Chiang , Yanai Goichi , Yang Sin-Yu , Canning Priyadarshini , Satou Yoshio , Kawagoe Masako , Sumi Shoichiro ,

Related products :

Catalog number Product name Quantity
25067-34-9 Poly(vinyl alcohol-co-ethylene) 1g
orb60796 GSK1292263 GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. For research use only. 10 mg
orb60409 Repaglinide Repaglinide is for the treatment of type II diabetes. For research use only. 50 mg
orb60315 Streptozotocin Streptozotocin(Streptozocin, Zanosar, STZ) is a naturally occurring chemical used in cancer chemotherapy and Type 1 diabetes treatment. For research use only. 500 mg
EIAAB39273 Homo sapiens,Human,Islet cell antigen 12,SOX13,SRY (Sex determining region Y)-box 13,Transcription factor SOX-13,Type 1 diabetes autoantigen ICA12
18-272-195620 SOX13 - Rabbit polyclonal to SOX13; Type 1 diabetes autoantigen ICA12; Islet cell antigen 12 Polyclonal 0.05 mg
orb60627 Glipizide Glipizide(Glucotrol) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. For research use only. 500 mg
JD1H1_R8S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:8 SignArrays
JD1H1_F8S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:8 SignArrays
JD1H1_R12S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:12 SignArrays
JD1H1_R24S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:24 SignArrays
JD1H1_R2S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:2 SignArrays
JD1H1_R4S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:4 SignArrays
JD1H2_R4S Diabetes type 1 (juvenil diabetes) ,JD1H2:4 SignArrays
JD1H2_R2S Diabetes type 1 (juvenil diabetes) ,JD1H2:2 SignArrays
JD1H1_F4S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:4 SignArrays
JD1H1_F2S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:2 SignArrays
JD1H1_B2S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1,2 SignArrays
JD1H1_B4S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1,4 SignArrays
JD1H1_B8S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1,8 SignArrays
JD1H1_F12S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:12 SignArrays
JD1H1_B12S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1,12 SignArrays
JD1H1_B24S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1,24 SignArrays
JD1H1_F24S Diabetes Type 1 (Juvenil Diabetes) ,JD1H1:24 SignArrays
orb60688 Acadesine Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. 25 mg


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur