Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29778746
Publication Date : //

Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats.

Vascular dementia (VaD) is the second most common form of senile dementia, embraces memory deficits, neuroinflammation, executive function damage, mood and behavioral changes and abnormal cerebral blood flow. The purpose of the study was to explore the therapeutic potential of betulinic acid in bilateral common carotid artery occlusion (BCCAO) induced VaD in experimental rats. VaD was induced by BCCAO in rats and betulinic acid (10 and 15 mg/kg/day po) was administered 1 week after surgery. The cerebral blood pressure of the animal was recorded before and after the treatment using Laser Doppler flow meter. Object recognition task for non-spatial, Morris water maze for spatial and locomotor activity was performed to evaluate behavioral changes in rats. At the end of the study, animals were decapitated and hippocampus was separated to perform biochemical, neuroinflammatory and second messengers cAMP/cGMP analysis. Histology was done to study the brain pathophysiology. BCCAO surgery was able to significantly impaired memory in rats as observed behavioral and biochemical parameters. Moreover, BA demonstrated a neuroprotective effect in a dose-dependent manner. BA was able to re-establish cerebral blood flow, restore behavioral parameters and showed significant improvements in the as cAMP,cGMP and BDNF levels, restrain the oxidative stress and inflammatory parameters. In histopathology, betulinic acid treated groups showed a decrease in microgliosis and less pathological abnormalities comparable to diseased rat's brain. The observed effect might be attributed to the neuroprotective potential of betulinic acid and its ability to restore cognitive impairment and hippocampal neurochemistry in VaD.

Authors : Kaundal Madhu , Zameer Saima , Najmi Abul Kalam , Parvez Suhel , Akhtar Mohd ,

Related products :

Catalog number Product name Quantity
orb61426 Betulinic acid Betulinic acid For research use only. 1 g
EH1324 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Elisa Kit 96T
EIAAB30283 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,Pde10a,Rat,Rattus norvegicus
CSB-EL017681HU Human cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A) ELISA kit 96T
EIAAB30284 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,Mouse,Mus musculus,Pde10a
EIAAB30285 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A,Homo sapiens,Human,PDE10A
E1158m ELISA Kit FOR cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; organism: Mouse; gene name: Pde10a 96T
E1158h ELISA Kit FOR cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; organism: Human; gene name: PDE10A 96T
10376-50-8 Acetyl betulinic acid Acetyl betulinic acid 1g
PC36112 E18 Primary Mouse Hippocampal Astrocytes, 4 Hippocampal Pair
PC36112 E18 Primary Mouse Hippocampal Astrocytes, 4 Hippocampal Pair 1
PC35113 E18 Primary Mouse Hippocampal Neurons, 4 Hippocampal Pair
PC35113 E18 Primary Mouse Hippocampal Neurons, 4 Hippocampal Pair 1
82801-73-8 cGMP Dependent kinase inhibitor peptid cGMP Dependent Kina 1g
1552-25 Betulinic acid 3β-Hydroxy-20(29)-lupaene-28-oic acid 25 mg
1552-100 Betulinic acid 3β-Hydroxy-20(29)-lupaene-28-oic acid 100 mg
orb60903 Oleanolic Acid Oleanolic acid(Caryophyllin) is a naturally occurring triterpenoid, widely distributed in food and medicinal plants, related to betulinic acid. It is relatively non-toxic, antitumor, an 25 mg
472-15-1 Betulinic acid Betulinic acid 1g
EIAAB29260 Homo sapiens,Human,huOKL38,OKL38,OSGIN1,Ovary, kidney and liver protein 38,Oxidative stress-induced growth inhibitor 1,Pregnancy-induced growth inhibitor OKL38
27739-1 Betulinic acid 25 mg
27739-2 Betulinic acid 50 mg
M27825208 Betulinic acid CAS: [472-15-1] 100 mg
BP0271 Betulinic acid 100mg
BP0271 Betulinic acid 1000mg


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur