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Pubmed ID :29788447
Publication Date : //

Varicella Zoster Virus Induces Nuclear Translocation of the Neurokinin-1 Receptor, Promoting Lamellipodia Formation and Viral Spread in Spinal Astrocytes.


Varicella zoster virus (VZV) can present as a myelopathy with spinal astrocyte infection. Recent studies support a role for the neurokinin-1 receptor (NK-1R) in virus infections, as well as for cytoskeletal alterations that may promote viral spread. Thus, we examined the role of NK-1R in VZV-infected primary human spinal astrocytes (HA-sps) to shed light on the pathogenesis of VZV myelopathy.

Authors : Bubak Andrew N , Como Christina N , Blackmon Anna M , Frietze Seth , Mescher Teresa , Jones Dallas , Cohrs Randall J , Paucek Petr , Baird Nicholas L , Nagel Maria A ,

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