Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29791862
Publication Date : //

Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance.


The leading cause of cancer death in women around the world is breast cancer. The aromatase inhibitors (AIs) are considered - as first-line treatment for estrogen receptor-positive (ER) breast tumors, in postmenopausal women. Exemestane (Exe) is a powerful steroidal AI, however, despite its therapeutic success, Exe-acquired resistance may occur leading to tumor relapse. Our group previously demonstrated that autophagy acts as a pro-survival process in Exe-induced cell death of ER sensitive breast cancer cells. In this work, the role of autophagy and its relationship with the PI3K/AKT/mTOR pathway in Exe-acquired resistance was explored. In that way, the mechanism behind the effects of the combination of Exe with pan-PI3K, or autophagic inhibitors, was studied in a long-term estrogen deprived ER breast cancer cell line (LTEDaro cells). Our results indicate that Exe induces autophagy as a cytoprotective mechanism linked to acquired resistance. Moreover, it was demonstrated that by inhibiting autophagy and/or PI3K pathway it is possible to revert Exe-resistance through apoptosis promotion, disruption of cell cycle, and inhibition of cell survival pathways. This work provides new insights into the mechanisms involved in Exe-acquired resistance, pointing autophagy as an attractive therapeutic target to surpass it. Thus, it highlights new targets that together with aromatase inhibition may improve ER breast cancer therapy, overcoming AIs-acquired resistance.

Authors : Amaral Cristina , Augusto Tiago Vieira , Tavares-da-Silva Elisiário , Roleira Fernanda M F , Correia-da-Silva Georgina , Teixeira Natércia ,

Related products :

Catalog number Product name Quantity
20-783-74648 MOUSE ANTI HUMAN BREAST CANCER RESISTANCE PROTEIN - Placenta-specific ATP-binding cassette transporter; Breast cancer resistance protein; Mitoxantrone resistance-associated protein; CD338 antigen; CDw 1 ml
U0960h CLIA ABCG2,ABCP,ATP-binding cassette sub-family G member 2,BCRP,BCRP1,Breast cancer resistance protein,CDw338,Homo sapiens,Human,Mitoxantrone resistance-associated protein,MXR,Placenta-specific ATP-bi 96T
E0960h ELISA ABCG2,ABCP,ATP-binding cassette sub-family G member 2,BCRP,BCRP1,Breast cancer resistance protein,CDw338,Homo sapiens,Human,Mitoxantrone resistance-associated protein,MXR,Placenta-specific ATP-b 96T
E0960h ELISA kit ABCG2,ABCP,ATP-binding cassette sub-family G member 2,BCRP,BCRP1,Breast cancer resistance protein,CDw338,Homo sapiens,Human,Mitoxantrone resistance-associated protein,MXR,Placenta-specific 96T
MC-236 BCRP (Breast Cancer Resistance Protein) 1 mL
MC-236 BCRP (Breast Cancer Resistance Protein) 1 mL
FP-0006 Breast cancer ANTIESTROGEN resistance 3 protein 10ug
MC-226 Breast Cancer Resistance Protein (BCRP, AGCG2) 1 mL
FP-0006 Breast cancer ANTIESTROGEN resistance 3 protein 10 ug
MC-226 Breast Cancer Resistance Protein (BCRP, AGCG2) 1 mL
MC-236 BCRP (Breast Cancer Resistance Protein) BXP_21 1 mL
MC-236 Antibodies: BCRP (Breast Cancer Resistance Protein) Clone: BXP-21 1 mL
EH2694 Breast Cancer Anti Estrogen Resistance 1 Elisa Kit 96T
E12857h Human Breast Cancer Anti Estrogen Resistance 1 ELI 96T
MC-226 Breast Cancer Resistance Protein (BCRP, AGCG2) BXP_34 1 mL
201-20-0605 BCAR1{breast cancer estrogen resistance 1}rabbit.pAb 0.1ml
MC-236 BCRP (Breast Cancer Resistance Protein) Clone BXP_21 1 mL
201-20-7185 BCRP_ABCG2_BXP-21{breast cancer resistance protein}rabbit.pAb 0.1ml
Breast - BRC1502 Breast cancer array, non_overlapping with BRC1501, consists of duplicated 70 cases covering all the common types of breast cancer and 5 cases of normal and other non_malignant breast tissues. 1.1mm
Breast - BRC1501 Breast cancer array consists of duplicated 70 cases covering all the common types of breast cancer and 5 cases of normal and other non_malignant breast tissues. 1.1mm
Breast - BRC961 Breast cancer array consists of duplicated 36 cases covering all the common types of breast cancer and 12 cases of normal and other non_malignant breast tissues. 1.5mm
MC-226 Breast Cancer Resistance Protein (BCRP, AGCG2) Clone BXP_34 1 mL
FP-0006 Breast cancer ANTIESTROGEN resistance 3 protein ; SH2-Domain: BCAR3 10ug
EM783 Breast cancer anti-estrogen resistance protein 3 Elisa Kit 96T
gen13523 ABCG2_HUMAN Breast cancer resistance protein ELISA tesk kit 1


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur